Anti-Inflammatory And Immunosuppressant Drug

Front 1

What are the anti-inflammatory agents?

Back 1

1. Glucocorticoids

2. Non-steroidal anti inflammatory drugs (NSAIDs)

Front 2

What are three major actions of NSAIDs?

Back 2

1. Anti-inflammatory action

2. Analgesic effect

3. Antipyretic effect

Front 3

Anti-inflammatory action

Back 3

1. Vasodilator prostaglandin (PGE2) decrease

2. Resulting to less oedema

Front 4

Analgesic effect

Back 4

1. Decreased prostaglandin generation

2. Less sensation of nociceptive nerve endings to inflammatory mediators.

Front 5

Antipyretic effect

Back 5

1. Decreased mediator prostaglanding that is responsible for elevating the hypothalamic set-point of temperature control.

Front 6

What are the clinical use of NSAIDs

Back 6

Rheumatoid arthritis

Gout
Headache

To lower temperature

Front 7

What are the unwanted effects of NSAIDs

Back 7

Inhibition of housekeeping enzyme (COX1)

Nausea

Vomit

Gastric

Skin reaction

Liver disorders

Front 8

What aspirin cause

Back 8

Irreversible inactivation of COX1 and COX2

Inhibit platelet aggregation

Front 9

Aspirin metabolize in

Back 9

Liver

Front 10

Unwanted effect of aspirin

Back 10

Gastric bleeding

Dizziness

Deafness (large dose)

Front 11

Paracetamol commonly used as

Back 11

Non-narcotic analgesic-antipyretic agent

Front 12

Paracetamol is selective inhibitor of

Back 12

COX3

Front 13

Toxic dose of paracetamol causing the drug to

Back 13

Converted by mixed function oxidase to N-acetyl-p-benzoquinone imine and react with proteins and kill the cell

Front 14

What is the used of Anti-histamine

Back 14

for allergic reactions including allergic rhinitis,urticarial, insect bites and drug hypersensitives.

Front 15

What is anti-emetics

Back 15

Prevention of motion sickness or other causes of nausea

Front 16

What is the action of immunosuppressant drugs?

Back 16

Most act in the induction phase of immunological response, reducing lymphocyte proliferation (rapid increase in number)

Some inhibit aspects of the effector phase of white blood cell.

Front 17

Agent that inhibit Interleukin 2 (IL-2) production or action?

Back 17

Ciclosporin

Front 18

Agent that inhibit cytokine gene expression

Back 18

Corticosteroids

Front 19

Agent that inhibit purine and pyrimidine synthesis

Back 19

Azathioprine

Front 20

Agent that block the T- cell surface molecule involve in signaling

Back 20

Monoclonal antibodies

Front 21

What are the clinical use of immunosuppressant drugs?

Back 21

To suppress rejection of transplanted organs and tissue

TO suppress graft versus host diseases in bone marrow transplant

TO treat a variety of conditions with auto immune component in their pathogenesis

Front 22

Arachidonate metabolites are

Back 22

Eicosanoids

Front 23

Outline the action of anti inflammatory drugs

Back 23

1. Glucocorticoids inhibit transcription of the gene for COX2.