Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
Penicillins - Mechanism of Resistance
|
1. formation of beta-lactamases (penicillinase);
2. structural alterations in penicillin-binding proteins (PBPs) |
|
Macrolides - Mechanism of Resistance
|
production of methylase that adds a methyl group to the ribosomal drug-binding site
|
|
Aminoglycosides - Mechanism of Resistance
|
plasmid-mediated production of inactivating enzymes, such as enzymes that phosphorylate, adenylate or acetylate the drug.
Anaerobes are naturally resistant because these drugs are taken up into bacteria by an oxygen-dependent transport system |
|
Fluroquinolones - Mechanism of Resistance
|
1. decreased ability to accumulate the drug;
2. mutation in the target enzyme's fluoroquinolone-binding site |
|
Vancomycin - Mechanism of Resistance
|
replacement of terminal D-ala by D-lactate at the drug-binding site
|