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37 Cards in this Set
- Front
- Back
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Phenytoin MOA
(Dilantin) |
Na channel blocker
"Low salt on Carbs is Lame and not Phun unless I have a Part Gin/Tonic" |
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Phenytoin Indication
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DOC:
Partial seizures Generalized tonic-clonic Status epilepticus Trigeminal neuralgia Cardiac Arrhythmias |
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Phenytoin Metabolism
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Highly plasma & tissue bound -> widely distributed
Conjugated -> inactive metabolites -> excreted in urine Low dose -> FOK (T1/2 = 24 hrs) High dose -> ZOK (saturates liver enzymes) |
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Phenytoin mnemonic
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"Having such a Phun time killing babies (teratogenic) w/ Partial Gin/Tonic my heart skipped a beat (tx arrhythmias) I stated I had a headache (Trigem Neuralgia) & my dick in a chain which ANGHRS HM
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Phenytoin SE
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ANGHRS HM:
Ataxia Nystagmus Gingival Hyperplaisa Rash SJS Hepatitis Megaloblastic Anemia |
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Phenytoin Drug Interactions
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Drug interactions:
Dicumarol, cimetadine, valproic acid -> inhibit metabolism Barbiturates, carbamazepine -> ↑ metabolism Phenytoin -> ↑ metabolism of carbamazepine, dicumarol, oral contraceptives, cyclosporine |
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Carbamazepine
(Tegretol) |
Na channel blocker
"Low salt on Carbs is Lame and not Phun unless I have a Part Gin/Tonic" |
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Carbamazepine indications
(Tegretol) |
DOC:
Partial seizures Generalized tonic-clonic Severe cases -> w/ phenytoin Trigeminal neuralgia Alcohol withdrawal Mania -> bipolar affective disorder |
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Carbamazepine Metabolism
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Plasma bound & slowly distributed
By liver microsomal enzymes -> produce microsomal enzyme induction (↓ t1/2 w/ chronic use) -> excreted in urine |
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Carbamazepine SE
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Erythematous skin rash, agranulocytosis, aplastic anemia -> liver toxicity
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Carbamazepine mnemonic
(Tegretol) |
Carbs from EtOH in my Part Gin/Tonic gave me a headache (Trigem Neuralgia), made me a crazy red faced asian (SJS rash, test in Asians) w/ glasses (diplopia) eating bones and up and kill my liver (agranulocytosis & induce enzymes also kill liver)
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Lamotrigine MOA
(Lamictal) |
Na+ blocker
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Lamotrigine mnemonic
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Absence of Myo Sugar (glucuronidation) enzymes made me fall asleep on llama whose rough fur gave me a rash -> wake up with cross eyes & rash looking like zit-faced 16yo
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Lamotrigine Indications
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Partial seizures
Generalized tonic-clonic Absence & Myoclonic |
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Lamotrigine SE
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life-threatening dermatitis (llama's fur -> give rash)
DO NOT USE in pt <16 yo NO enzyme induction |
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Ethosuximide MOA
(Zarontin) |
T-type Ca inhibitor
"Ethos sux Val's Titty's of Milk until Absent" (Inhibit low-threshold Ca currents (T-currents) in thalamic neurons Absence seizures -> activation of T-type calcium channels in thalamus) |
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Valproic acid MOA
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1) T-type Ca inhibitor
"Ethos sux Val's Titty's of Milk until Absent" 2) Inhibit T-type Ca channels 3) Increases Na channel inactivation Prolong recovery of Na channel from inactivation -> ↓ Na influx |
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Ethosuximide Indications
(Zarontin) |
Absence sz (DOC)
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Valproic Acid MOA
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1) Inhibits T-Type Ca2+ channels
2) Prolongs Na channel inactivation 3) Inhibits GABA transaminase -> increased GABA in brain DOC for: 1) Pt w/ Absence & Gen. Tonic-Clonic 2) Myoclonic sz Also tx: Absence, Manic (bipolar), Migraine "Val was Absent minded 2yo c/o too many Gin/Tonic at MLB got a migraine so ate a steak even though not hungry -> got fat |
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Valproic acid mnemonic
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"Val was Absent minded 2yo c/o too many Gin/Tonic at MLB got a migraine so ate a steak even though not hungry -> got fat & EtOH kills kids & liver
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Ethosuximide mnemonic
(Zarontin) |
Sucking -> agitation & bulemia (NVD) -> tired, no prot, bad skin, chained to H2O fountain for a long time
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Ethosuximide SE
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transient fatigue, lethargy, GASTRIC distress, SKIN reactions, AGITATION
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Ethosuximide metab
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long (40-50 hrs)
NOT protein bound Hydroxylation & conjugation -> inactive metabolites |
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Gabapentin mnemonic
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Fat & tired, can't walk, Says GAGA c/o CNS distress, drinks Part Gin/tonic for neuropathic pain but does not affect his liver
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Pregabalin mnemonic
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Pregaba has five bros named GABA (fibromyalgia)
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Diazepam mnemonic
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Diaz & Lora are acute epileptic couple (status epilepticus) who run
Diaz sprints Lora marathons |
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Lorazepam mnemonic
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Diaz & Lora are acute epileptic couple (status epilepticus) who run
Diaz sprints Lora marathons |
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Clonazepam mnemonic
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Clones are invincible, absent minded, absent tone, absent muscle, knocked out (absent consciousness)
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Phenobarbital mnemonic
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Barbi irritated/disturbed by feverish kids drank Part Gin/tonic to knock self out for 100 hours and up liver enzymes
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Adjunct drugs mnemonic
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I add partial clouds to LEVETATE to TOP of TAIGA ZONE
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Topiramate mnemonic
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Salty Gaba Kainite pirates drink Gin/Tonic to Kill migraine & Can't think or remember, lost wt c/o no protein in diet
Salty = Blocks Na, ups GABA inhib, decreases Kainite on AMPA-R |
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Tiagabine mnemonic
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Tiger made me dizzy & nervous c/o wanted to eat me as protein so shot him w/ my one GAT
(GAT = Gat 1 isoform reuptake; inhibit -> increase GABA in brain) |
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Levetiracetam mnemonic
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levetate in PART of my sleep for 6-8 hours
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Zonisamide mnemonic
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Kids go to hot zone get renal stones for PART of 60hrs
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Felbamate mnemonic
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Lenny feels up resistant parts of SoCal Girls who burn his bones & liver in reply
(SoCal Girls = Block Sodium, Calcium, Glycine co-activation of NMDA-R) |
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Anti-epileptics to monitor liver (liver processes)
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Val Fel on a Tiger and hurt his liver, wasn't Phun
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Anti-epileptics processed by kidney
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Gaby's Pee reached the Top Level of her Kidney
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