Ans Drugs

Front 1

Location of ANS receptors
Nn
Nm
M1-3

Neurotransmitter?

Back 1

Nicotinic
Nn--in ganglia of PANS and SANS and adrenal medulla

Nm--skeletal muscle motor end plates (somatic NS)

Muscarinic 1-3
all organs/tissues innervated by postganglionic nerves of the PANS(most M3), SA node (M2)
thermoregulatory sweat glands (M1) of SANS

Acetylcholine (ACh)

Front 2

Norepinephrine (NE)

Back 2

neurotransmitter at most adrenoceptors in organs as well as in cardiac and smooth muscle
(Alpha or Beta)

Front 3

Dopamine (DA)

Back 3

Activates D1 receptors--vasodilation in renal and mesenteric vascular beds

Front 4

Epinephrine

Back 4

E--from adrenal medulla
activates most adrenoceptors

Transported in Blood (neurohumoral transmission)

Front 5

Muscarinic response and receptor in the eye

Back 5

M3
sphincter--miosis
ciliary muscle--accomodation

(alpha 1--radial muscle--mydriasis)

Front 6

Muscarinic response and receptor in the heart

Back 6

M2
SA--decreased heartrate
AV--decreased conduction velocity
(- chronotrophy)

Front 7

Muscarinic response and receptor in the lungs

Back 7

M3
bronchioles
contraction--bronchospasm

glands--increased secretion

Front 8

Muscarinic response and receptor in the GI tract
1. Stomach
2. Glands
3. Intestine

Back 8

1. M3--increased motility/cramps

2. M1--increased secretion

3. M3--contraction- diarrhea, involuntary defecation

Front 9

Muscarinic response and receptor in the Bladder

Back 9

M3 Contraction (detrusor), relaxation (Trigone/Sphincter), voiding, urinary incontinence

Front 10

Muscarinic response and receptor Sphincter

Back 10

M3--relaxation
exception: LES contracts

Front 11

Muscarinic receptor and response in Glands

Back 11

M3
Secretion--sweat (thermoregulatory)
Salivation
Lacrimation

Front 12

Muscarinic receptor and response in Blood Vessels

Back 12

M3
Dilation--via NO/endothelium derived relaxing factor
No innervation, no effects on indirect agonist

Front 13

Antimuscarinic Drug-prototype

Back 13

Atropine

Front 14

Second messanger mechanism for M1 receptor

Back 14

Gq coupled--DAG and IP3--Ca2+ (intracellular) increases

Front 15

Second messanger mechanism for M2 receptor

Back 15

Gi coupled--decreased adenylyl cyclase--decreased cAMP

Front 16

Second messanger mechanism for Nn and Nm

Back 16

no second messangers--activation (opening) of Na/K channels

Front 17

ANS innervation of blood vessels

Back 17

solely innervated by SANS--stimulation of autonomic ganglia--vasoconstriction (alpha 1)

Front 18

Blood vessels--effects of stimulation
Adrenergic receptor types and action

Back 18

Vasoconstriction- PVR, diastolic P afterload increase
alpha 1--arterioles/veins

Vasodilation
beta 2--all vessels

D1--renal and mesenteric-- increased GFR, RBF and Na+ excretion

Front 19

ANS innervation of GI tract

Back 19

Dominated by PANS--ganglionic stimulation--increased GI motility and secretions

Front 20

Adrenergic effects on Beta cells of Islets of Langerhans

Back 20

Beta 2--increase secretion of insulin

Alpha 2--decreased secretion of insulin

Front 21

Which adrenergic receptor stimulation inhibits lipolysis

Back 21

alpha 2
decreased lipolysis and thermogenesis

(alpha 1, beta 1,2 & 3 increase lipolysis and therm)