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64 Cards in this Set
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Metyrosine |
Inhibits tyrosine hydroxylase to prevent L-DOPA formation |
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Reserpine |
Inhibits vesicular storage of Dopamine |
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DRUGS THAT STIMULATE EXOCYTOSIS |
Tyramine Ephedrine Amphetamine AT II Alpha-latrotoxin |
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DRUGS THAT INHIBIT EXOCYTOSIS |
Guanethidine Guanadrel Bretylium |
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REUPTAKE INHIBITORS |
Tricyclic antidepressants Cocaine Reboxetine |
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Product of norepinephrine and epinephrine metabolism |
3-methoxy-4-hydroxymandelic acid or vannilylmandelic acid |
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Product of metabolism of Dopamine |
Homovanilic acid |
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1st line cardiac stimulant 1st line agent for anaphylaxis and anaphylactic shock
can be used as a vasoconstrictor (+ lidocaine) |
Epinephrine or Adrenaline |
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A pivalic acid ester of epinephrine used to manage glaucoma |
DIPIVEFRIN |
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1st line agent for septic shock |
Norepinephrine/Noradrenaline/Levarterenol |
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Used to manage acute heart failure complicated by oliguria or anuria Management of septic shock and cardiogenic shock |
Dopamine |
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Toxic effects due to alpha 1 overstimulation |
Vasoconstriction = digital necrosis |
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Toxic effects of beta 1 overstimulation |
Ventricular tachyarrhythmias |
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A non selective beta agonist used as an alternative during shock states and for management of AHF |
Isoproterenol aka. Isoprenaline |
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A beta 1 selective agonist used as a FIRST LINE agent for cardiogenic shock |
Dobutamine |
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Used for pharmacological stress test to determine the cardiac function |
DOBUTAMINE + DIPYRIDAMOLE |
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The only beta 2 selective agonist administered subcutaneously |
TERBUTALINE |
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Off label use of terbutaline |
TOCOLYTIC (mgt of preterm labor) |
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Toxic effects of beta 2 agonists |
HYPOkalemia Tremors |
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Local toxic effect of alpha 1 selective agonist administered intranasally |
Rhinitis medicamentosa or rebound congestion |
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Alpha 2 selective agonist used for mgt of glaucoma |
Apraclonidine and Brimonidine |
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Alpha 2 selective agonist used as an alternative for management of HTN (rapid acting) and ADHD |
Clonidine |
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2 phases of effect of CLONIDINE |
Initial : vasoconstriction (transient) Final: lowers blood pressure (lasting) |
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Produces POSITIVE coombs test |
Methyldopa |
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Dopamine 1 selective agonist used as an alternative for hypertensive crisis |
Fenoldopam |
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1st line management of ADHD |
Methylphenidate alt: Amphetamine |
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Centrally acting symphatomimetics used as an ANOREXIANTS |
Phentermine Phenmetrazine Phenylpropanolamine |
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Centrally acting sympathomimetics used in the management of Narcolepsy |
Phentermine Amphetamine |
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Used in the management of pheochromocytoma (excessive amounts of epinephrine) |
Alpha blockers (alpha 2 blockers) Beta blockers |
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Used in the management of Raynauds syndrome |
Alpha blockers (alpha 2) CCB's (dipine) |
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Used in the mgt of HTN and urinary retention in BPH patients but has a toxic effect called FIRST DOSE PHENOMENON |
Alpha 1 blockers |
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An alpha blocker used in the management of erectile dysfunction |
Phentolamine |
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An alpha blocker used in the management of Carcinoid syndrome (90% production of serotonin) |
Phenoxybenzamine |
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Non selective beta blockers are contraindicated in? |
Patients with bronchial asthma |
NADOLOL SOTALOL TIMOLOL PROPRANOLO |
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Beta blockers that are not associated with rebound hypertensions (low risk) |
BETA BLOCKERS WITH intrinsic sympathomimetic activity (ISA) = beta 1 antagonist and beta 2 agonist |
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Beta blockers with membrane stabilizing action that possess local anesthetic effect, not to be instilled in the eye |
Pindolol Propranolol Acebutolol Labetalol Metoprolol
PinPALM |
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MOST CARDIOSELECTIVE BETA BLOCKER |
Nebivolol |
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Beta blockers used in the management of stable heart failure |
Bisoprolol Metoprolol succinate Carvedilol Nebivolol
Biso Met Carve and Nebi |
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Beta blockers used in the management of glaucoma |
Timolol and Betaxolol |
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A beta blocker used in the management of sympathetic symptoms of hyperthyroidism, prophylaxis of acute migraine headache and management of stage fright |
Propranolol |
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A toxic effect of beta blockers that is to be considered especially if the patients has diabetes |
It masks hypoglycemic symptoms |
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Inhibits active uptake of choline |
Hemicholinium |
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Inhibits vesicular storage of Acetylcholine |
Vesamicol |
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Stimulator of exocytosis of Acetylcholine |
Alpha latrotoxin |
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Inhibitor of exocytosis of Acetylcholine |
Botulinum toxin |
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Parasympathomimetic used in the management of Alzheimers disease |
CNS ACTING anticholinesterase Tacrine Donepezil Galantamine Rivastigmine |
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Best antidote in the treatment of anticholinergic poisoning (for peripheral signs and symptoms only) |
Neostigmine |
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Treatment of paralysis due NMB toxicity |
Neostigmine (intermediate acting, direct acting parasympathetic) and Endrophonium (short acting, direct acting parasympathetic) |
Curare derivatives, non depolarizing |
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Management of non obstructive ileus administered subcutaneously |
Physostigmine (intermediate indirect acting parasympathetic) Pilocarpine (alkaloid, muscarinic selective direct acting parasympathetic) |
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Parasympathomimetic used in the management of smoking cessation |
Nicotine Lobeline Varenicline
NICOTINIC SELECTIVE ALKALOIDS, DIRECT ACTING |
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Parasympathomimetic used in the management of urinary retention |
Betanechol (urecholine) |
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Used in the pulmonary challenge test for provocative test for bronchial hyperactivity |
Metacholine |
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Antimuscarinic used in the management of motion sickness |
Scopolamine |
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TWILIGHT SLEEP |
Scopolamine + Morphine |
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Antimuscarinics used in the management of EPS and parkinsonism |
Trihexyphenidyl, Benztropine, Diphenhydramine |
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M1 blocker used in the management of hyperacidity |
Pirenzepine Telenzepine |
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M3 antagonist used in the management of Hypermotility disorder and Urinary incontinence |
Methscopolamine Glycopyrrolate Hyoscine Dicycloverine Oxybutinine Scopolamine |
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Used as a preanesthetic agent to relax skeletal muscle prior to surgery and management of spastic disorder |
Nm blockers |
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This drug acts by irreversibly activating Nm receptor, and it has two phase of effect I: skeletal muscle contraction II: relaxation or paralysis |
Depolarizing Nm blocker/Succinylcholine |
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Causes malignant hyperthermia |
Succinylcholine |
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acts by blocking Nm receptors causing immediate paralysis |
Nondepolarizing Neuromuscular blocker/Reversible Neuromuscular |
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Used to treat malignant hyperthermia |
Dantrolene |
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Type 1 NONDEPOLARIZING NM |
ISOQUINOLINE (-curium) Atracurium Tubocurarine |
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Type 2 NONDEPOLARIZING NM |
STEROIDAL (-curonium) Pancuronium Rocuronium |
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