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31 Cards in this Set
- Front
- Back
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anemia
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def in size or # of RBC OR amt hemoglobin they contain that limits exchange of O2 & CO2 b/w blood/tissues
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aplastic anemia
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normochromic-normocytic anemia accompanied by def of all formed elements in blood; caused by exposure to toxic chem, ionizing radiation, meds, unknown
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ferritin
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iron apoferritin complex; one of the chief storage forms of iron
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hematocrit
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volume percentage of erythrocytes in the blood
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heme iron
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organic form that comes from meat, fish, poultry
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hemochromatosis
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genetically determined form of iron overload that results in progressive hepatic, pancreatic, cardiac and other other organ damage
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hemoglobin
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conjugated protein containing 4 heme groups and globin; oxygen-carrying pigment of erythrocytes
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hemolytic anemia
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amenia caused by shortened survival of mature RBC
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hepcidin
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peptide hormone made in liver; principal regulator of systemic iron homeostasis; controls plasma iron [ ] & tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron mobilization from hepatic stores
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holotranscobalamin II
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vitamin B12 attached to the beta-globulin, the major circulating vitamin B12 delivery protein
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hypochromic
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characterized by deficient hemoglobin content of RBC
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intrinsic factor
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glycoprotein secreted by gastric glands that is necessary for absorption of exogenous vitamin B12 by ileal cell surface receptors for IF-B12 complexes
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iron def anemia
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production of small erythrocytes and diminished level of circulating hemoglobin; the last stage of iron deficiency which represents the end point of a long period of iron deprivation
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macrocytic anemia
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larger-than-normal RBC and increased mean corpuscular volume and mean corpuscular hemoglobin
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meat, fish and poultry factor
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good sources of well absorbed heme iron
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megaloblastic anemia
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smaller-than-normal erythrocytes and less circulating hemoglobin; characteristic of iron def and thalassemia
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neg vit B12 bal
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vit B12 pre-deficiency stage
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non-heme iron
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iron that is not part of hemem complex
eggs, grains, vegetables, fruits sm amts fish, meat, poultry |
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pernicious anemia
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macrocytic, megaloblastic anemia caused by deficiency of vit B12, secondary to lack of IF
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plasma
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liquid portion of whole blood that includes coagulation factors
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plasma
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liquid portion of whole blood that includes coagulation factors
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protoporphyrin
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iron containing portion of the respiratory pigments that when combined w/protein, forms hemoglobin or myoglobin
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serum
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liquid portion of whole blood w/o coagulation factors
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sickle cell anemia
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chronic hemolytic anemia, occurring most commonly in blacks
caused by homozygous inheritance of hemoglobin S defective hemoglobin synthesis that causes RBC to be sickle shaped |
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sideroblastic anemia
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microcytic, hypochromic anemia characterized by derangement in final pathway of heme synthesis, leading to buildup of iron-containing immature RBC
responsive to pharmacologic doses of B6 |
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soluble serum transferrin receptors
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molecules generated on surface of rbc in response to need for iron that have broken away from RBC and are in serum;
measure of early iron deficiency |
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thalassemia
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anemia secondary to defective synthesis of the globin part of hemoglobin
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total iron-binding capacity
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capacity of transferrin to take on or b/c saturated w/ iron
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transferrin
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globulin that binds and transports iron from the gut wall to the tissue cells
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transferrin receptor
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molecule on surface of RBC that binds transferrin the transport form of iron
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transferrin saturation
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measure of amt of iron bound to transferrin
gauge of iron supply to tissues percent saturation 5 serum iron/TIBC x 100 |
