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82 Cards in this Set

  • Front
  • Back

Anatomy vs. Physiology

Body structure vs. Body function

Gross Anatomy

What can we see w/ the naked eye?

Cytology vs. Histology

Studying cells vs. studying tissues

Superior/Inferior

Up/Down

Medial/Lateral

Towards the middle/towards the side

Anterior/Posterior

Front/Back

Proximal/Distal

Towards torso/away from torso

Coronal


Transverse


Midsagittal

Divides body into:


Front/Back


Upper/Lower


Left/Right

Homeostasis

"Tendency to maintain stable internal environment despite continuously changing outer environment"

"Antagonistic homeostatic control"

Two antagonistic systems balance each other out to maintain homeostasis


Ex. Insulin, Glucagon, and body glucose levels

Insulin

Lowers glucose levels by encouraging glucose uptake in most cells and promoting glycogen formation in the liver

Glucagon

Raises glucose levels by breaking down glycogen stores in the liver

Order of reaction to stimulus

1. Stimulus


2. Receptors


3. Control center


4. Effectors


5. Response

Setpoint

The point at which homeostasis exists.




NOTE: the set point can change


Ex. acclimation to altitude = More RBCs

Feedback

When a system's output is returned to its input to affect future output

Neg. Feedback vs. Pos. Feedback

Shuts down input/Further stimulates input

Neg. Feedback

When output opposes further action on the input.


Most common feedback loop: prevents sudden changes in the body.


Ex. blood glucose system

Pos. Feedback

When output amplifies stimulus, causing increased input.


Causes sudden bodily change that are short-lived


Ex. contractions during childbirth




NOTE: Pos. Feedback loops cannot terminate themselves

Plasma Membrane: Functions

1.Physical barrier


2. Selective permeability


3. Intercellular communications


4. Anchoring to other cells

Membrane Transport

Transport of gases and/or molecules across a cell membrane

Paracellular vs. Transcellular transport

Para - between two cells


Trans - directly through a cell

Passive vs. Active transport

Passive - no ATP required


Ex. diffusion, channel & carrier mediated




Active - ATP required



Passive Transport

Uses only the energy from the concentration gradient (Hi to Lo)

Active Transport

Requires energy to move against the concentration gradient (Lo to Hi)

Simple Diffusion

Random spread of molecules until concentration gradient achieved throughout




NOTE: diffusion rate inversely proportional to molecule size and membrane permeability

Osmosis

Diffusion of water over selectively permeable membrane




NOTE: affected by presence of solutes

Facilitated Diffusion

Diffusion across a membrane, facilitated by carrier proteins.

Bulk Filtration

Everything in a solution moves in one direction

Ion Channels

Channel proteins specifically for passive transport of ions




NOTE: very fast

Mechanisms for opening ion channels

1. Voltage


2. Intra- or extra-cellular ligands/keys


3. Mechanically opened

Transport-Carriers

Carrier proteins designed for active or passive transport; not very fast




NOTE: works like the Panama canal

Occlusion State

The state when a transport-carrier proteins in closed on both sides of the membrane

3 Types of transport carrier:

Uniport (one way)


Symport (two-lane)


Antiport (two-way)

Primary Active Transporter

Requires ATP to transport against gradient




Ex. Na/K transporter

Secondary Active Transporter

Uses the energy of other molecules traveling down concentration gradient to transport target molecule against gradient




Both symport and antiport can be secondary




Ex. Na/Glucose symport transporter

Why have active transporters?

Pumps help maintain gradients, which keep cells and body working.


Allow gradient to equalize, and everything stops working

Tissue

A group of cells performing similar functions, with similar structure and extracellular matrix composition

Organ

A collection of different tissues.


Ex. the skin

Types of Tissue (4)

1. Epithelial


2. Connective


3. Muscular


4. Skeletal

Function of Epithelial Tissue (4)

1. Physical protection


2. Selective permeability


3. Secretions


4. Sensation (ex. touch)

Types of Epithelial Tissue (5)

1. Exchange


2. Transport


3. Ciliated


4. Secretory


5. Protective

Modes of Secretory Epithelial Tissue (3)

1. Apocrine (Half-cell)


2. Merocrine (Vesicles)


3. Holocrine (Complete cell)

Types of Intercellular Junctions (4)

1. Tight (seals apical surface)


2. Adhering (holds cells together)


3. Desmosomes (holds cells together)


4. Gap (Cell communication)

Functions of Connective Tissue (6)

1. Protection


2. Structural support


3. Binding things together


4. Transport


5. Storage


6. Autoimmunity

Types of Connective Tissue (4)

1. Proper (Aerolar/Adipose Loose, Reg/Irreg/Elastic Dense)


3. Supporting (Hyaline/Fibro-/)


4. Fluid (Blood)

Types of Muscle Tissues (3)

1. Skeletal


2. Cardiac


3. Smooth

Characteristics of Skeletal Muscle Tissue

Striations, straight fibers w/ multiple nuclei

Characteristics of Cardiac Muscle Tissue

Striations, intercalcating discs, branching fibers

Characteristics of Smooth Muscle Tissue

Flat muscle cells, no striations

Types of Cell Aging (5)

1. Metaplasia (new tissue type)


2. Hypertrophy (cell size)


3. Hyperplasia (cell number)


4. Neoplasia (a tumor)


5. Atrophy (less tissue)

Metaplasia

One type of tissue gets replaced with another


Ex. Simple Columnar with Stratified Squamous in smokers

Hypertrophy

Increase in existing cell's size (ex. cardiac/muscular hypertrophy)

Hyperplasia

Increase in the number of cells in a tissue

Neoplasia

Uncontrollable cell growth, resulting in new tissue (a tumor)

Atrophy

Decrease in size of a tissue, either due to smaller cells or less cells

Types of Cell Death (2)

1. Apoptosis (Intended)


2. Necrosis (Unintended)

Major Mineral in Bone?

Hydroxyapatite

Functions of Skeletal System (4)

1. Structure, protection, and support of other organs


2. Attachment sites for muscles


3. Calcium and phosphate homeostasis


4. Blood cells and stem cell production

Mechanical Properties of Bone

Elastic


Yield point


Plastic


Failure point/Failure

Hysteresis

When a load enters the plastic region and then is lifted.

Anisotrophy

Property of how bone strength varies with direction of load on bone (ex. longitudinal vs. perpendicular to bone)

Types of Forces on Bone (2)

1. Tension


2. Compression


NOTE: exerted on side of the bone; inside is hollow/spongy bone

Osseous bone structure, from interior to exterior

Osteon (Central canal, concentric lamellae, canaliculi, lacunae), interstitial lamellae, circumferential lamellae

What are perforating canals?

They connect two or more central canals.

Bone cells (3)

1. Osteoblast (create)


2. Osteocyte (maintain)


3. Osteoclast (destroy)

Long bone structure (3)

1. Epiphysis (bone growth plate)


2. Metaphysis (whatever's not epi- or dia-)


3. Diaphysis (the main shaft)

Trabeculae

The narrow plates of bone that make spongy bone.

Functions of Cartilage (3)

1. Support of soft tissue


2. Joints/Articulations


3. Precursor for bone growth

Types of Cartilage (3)

1. Hyaline Cartilage (clear rubbery cartilage found between most long bone joints)


2. Fibrinous Cartilage (tough cartilage found between other bones, like the vertebrae)


3. Elastic Cartilage (wherever elasticity is needed, like the ears and nose)

Two types of cartilage growth

1. Interstitial (inside out)


2. Appositional (outside layer)

Why does cartilage heal slowly?

It is avascular, so it takes a while for necessary materials to reach the injury.


Fibrocartilage also replaces hyaline cartilage as scar tissue

Bone Development Types (3)

1. Intramembraneous ossification (growth of skull bones in babies)


2. Endochondrial ossification (new bone from epiphyseal plate)


3. Calcification (depositing of calcium into tissues)

Hormones that control Calcium Homeostasis

1. Parathyroid hormones (released when Ca is low; breaks down bone)


2. Calcitonin (release when Ca is high; decreases bone reapsorption)

Bone Remodeling

Normal process where old bone is broken down and replaced with new bone.

Bones in Skull?

8 Cranial bones, 14 Facial

Bones in Ribs?

1-7 Real ribs, 8-12 False ribs, 11-12 Floating ribs

Bones in vertebrae?

7 in Cervical area, 12 in Thoracic area, 5 in Lumbar, 1 in adult Sacrum, 1 in adult Coccyx

Foramen Magnum

Foramen (hole) through which nerve cord enters the skull.


NOTE: placement of FM can indicate bipedalness

Sutures in cranium?

1. Coronal (frontal/parietal)


2. Sagittal (Two halves of parietal)


3. Lamboidal (parietal/occipital)


4. Squamous (parietal/temporal)



Sternal Foramen

A hole in the xiphoid process that sometimes appears

Parts of the sternum (3)

1. Manubrium (where collarbones meet sternum)

2. Body (the middle part)


3. Xiphoid process (the bottommost part)

Costal cartilage

The cartilage that links most of the ribs to the sternum