Amino Acid Biochem Fn

Front 1

Non-polar groups (7)

Back 1

Gly-G ---- Ala-A ----- Pro-P ------ Val-V -----Leu-L------- Ile-I----- Met-M

Front 2

Aromatic R (3) -- tYYYr

Back 2

Phe-F------ Tyr-Y-------Trp-W

Front 3

Polar uncharged (5) --- asparagiNNNe

Back 3

Ser-S------Thr-T-------Cys-C------Asn-N------Gln-Q (most abund)

Front 4

Negative charged -1 (2) --- aspartATE ---- MSG (5C)

Back 4

Asp-D-----Glu-E (neurotransmitter)

Front 5

Positive charged +1 (3) -- aRRRg

Back 5

Lys-K------Arg-R------His-H

Front 6

OH ------------SH --------H2N-C=O----------COO-----------NH3-NH4 --- noncharged----- Arom

Back 6

ST---CM----NQ-----ED-------KRH---- GAPVLIM------FYW

Front 7

His positive when

Back 7

when pH<6.0 in pronated form --> low pH lots of H add H in

Front 8

Sickle cell --- less water soluble --- brittle ---- treatment

Back 8

Glu --> Val on #6 (neg - vs nonpolar) ---> noncharged less polar water is polar ----- crystalize ----- give more O2

Front 9

pH=pKa + log (B/A) -- protonation state (acid state) --> base/Acid

Back 9

--> pH determine the drug in its acid form or basic form

Front 10

What is the pH at which we have 10 times more of the acid form than the basic form for the drug “aspirin”? pKa=3.5

Back 10

pH=pKa + log (B/A) ---- pH = 3.5 + log (1/10) --> pH = 3.5 - 1 = 2.5 --- more acid in stomach ---- need enteric coating

Front 11

pI and buffer capacity

Back 11

at pI: drug has no charges ---- buffer in 1 pH unit of its pKa

Front 12

His pI --> use the point of 0 charged

Back 12

pI=(6.0+9.17)/2=7.59 (when it has both + and -)

Front 13

Protein cross-link Cys (curly hair)

Back 13

A disulfide bridge