Alpha And Beta Blockers

Front 1

Alpha-1 Receptors

Back 1

Post-Synaptic constriction of vascular smooth and dilation of pupil GTP activates PLC causing IP3 and DAG

Front 2

Beta-1 Receptors

Back 2

Myocardium of heart excites

Front 3

Beta-2 Receptors

Back 3

Vascular and Bronchial relaxation smooth muscle also some heart

Front 4

Beta-3 Receptors

Back 4

Adipose tissue breaks down

Front 5

Phenoxbenzamine
-Mechanism

Back 5

Irreversible Non-Selective Alpha Blockers

Front 6

Phenoxybenzamine
-Application

Back 6

Pheochromocytoma (use it before removing tumor because high levels of released catecholamines will not be able to overcome blockage)
Non-selective Alpha Blockers

Front 7

Phenoxbenzamine
-Toxcity

Back 7

Alpha blocker so causes hypotension and reflex tachycardia

Front 8

Phentolamine
-Mechanism

Back 8

Reversible Alpha Blockers

Front 9

Prazosin, doxasin
-Mechanism

Back 9

Alpha-1 Selective Blockers

Front 10

Terazosin
-Application

Back 10

Hypertension, urinary retention in BPH
alpha 1 antagonist

Front 11

Mirtazapine
-Mechanism

Back 11

Alpha-2 blockers

Front 12

Mirtazapine
-Application

Back 12

Depression

Front 13

Carvedilol
-Mechanism

Back 13

Nonselective Alpha and Beta antagonist

Front 14

Labetalol
-Mechanism

Back 14

Nonselective Alpha and Beta antagonist

Front 15

Acebutolol
-Mechanism

Back 15

Beta-1 selective antagonist (b1>b2)

Front 16

Metoprolol
-Mechanism

Back 16

Beta-1 selective antagonist (b1>b2)

Front 17

Atenolol
-Mechanism

Back 17

Beta-1 selective antagonist (b1>b2)

Front 18

Esmolol
-Mechanism

Back 18

Beta-1 selective antagonist (b1>b2) (short acting)

Front 19

Betaxolol
-Mechanism

Back 19

Beta-1 selective antagonist (b1>b2)

Front 20

Propranolol
-Mechanism

Back 20

Nonselective Beta antagonists (b1=b2)

Front 21

Mirtazapine
-Mechanism

Back 21

Alpha-2 blockers

Front 22

Mirtazapine
-Application

Back 22

Depression

Front 23

Carvedilol
-Mechanism

Back 23

Nonselective Alpha and Beta antagonist

Front 24

Labetalol
-Mechanism

Back 24

Nonselective Alpha and Beta antagonist

Front 25

Acebutolol
-Mechanism

Back 25

Beta-1 selective antagonist (b1>b2)

Front 26

Metoprolol
-Mechanism

Back 26

Beta-1 selective antagonist (b1>b2)

Front 27

Atenolol
-Mechanism

Back 27

Beta-1 selective antagonist (b1>b2)

Front 28

Esmolol
-Mechanism

Back 28

Beta-1 selective antagonist (b1>b2) (short acting)

Front 29

Betaxolol
-Mechanism

Back 29

Beta-1 selective antagonist (b1>b2)

Front 30

Propranolol
-Mechanism

Back 30

Beta non selective antagonist (b1=b2)

Front 31

Timolol
-Mechanism

Back 31

Nonselective Beta antagonists (b1=b2)

Front 32

Nadolol
-Mechanism

Back 32

Nonselective Beta antagonists (b1=b2)

Front 33

Labetalol
-Mechanism

Back 33

Nonselective Beta antagonists (b1=b2)

Front 34

Pindolol
-Mechanism

Back 34

Nonselective Beta antagonists (b1=b2)

Front 35

Beta Blockers
-toxicity (5)

Back 35

Watch out in diabetics, impotence, exacerbates Asthma, Cardiovascular effects (bradycardia, CHF, AV block), CNS adverse effects (sedation, sleep alterations)

Front 36

Beta-Blockers used in Hypertension because

Back 36

Hypertension--> decrease CO and renin secretion

Front 37

Beta-blockers used in Angina because...

Back 37

Decrease R and contractility resulting in less oxygen consumption

Front 38

Beta-blockers used in MI...

Back 38

Beta-blockers decrease mortality

Front 39

Beta-blockers used in SVT

Back 39

Decrease av conduction velocity class II antiarrhythmiac)

Front 40

Beta-blockers used in CHF

Back 40

slow progression of chronic failure

Front 41

Which beta-blocker used in Glaucoma and why?

Back 41

Timolol decreases secretion of aqueous humor

Front 42

Terbutaline
-Mechanism

Back 42

Selective B2 agonists

Front 43

Salmeterol
-Mechanism

Back 43

Selective b2 agonists

Front 44

Albuterol
-Mechanism

Back 44

Selective b2 agonists

Front 45

Metaproterenol
-Mechanism

Back 45

Selective b2 agonists

Front 46

Epinephrine
-Mechanism

Back 46

Alpha and Beta agonist at low doses selective for Beta-1

Front 47

Epinephrine
-Application

Back 47

Anaphylaxis, glaucoma (open angle), asthma, hypotension

Front 48

Norepinephrine
-Mechanism

Back 48

alpha-1, alpha-2>beta-1

Front 49

Norepinephrine
-Application

Back 49

Hypotension (but decrease renal perfusion)

Front 50

Isoproterenol

Back 50

Beta1=beta2 agonists

Front 51

Dopamine
-Mechanism

Back 51

D1=D2>b>alpha inotropic and chronotropic

Front 52

Dobutamine
-Mechanism

Back 52

B1>b2 Inotropic (weakens force of muscular contraction) but not chronotropic (doesn't change heart rate)

Front 53

Phenylepinephrine
-Mechanism

Back 53

Alpha-1>alpha-2

Front 54

Phenylepinephrine
-Application

Back 54

Pupil Dilation, vasoconstriction, nasal congestion

Front 55

Terbutaline
-Application

Back 55

reduces uterine contraction beta-2 agonist

Front 56

Ritodrine
-Application

Back 56

Reduces uterine contractions (Beta-2 agonists)

Front 57

Clonidine
-Mechanism

Back 57

Alpha-2 agonists, decreases central adrenergic outflow

Front 58

Clonidine
-Applications

Back 58

Hypertension especially with renal disease (no decrease in blood flow to kidney) Alpha-2 Agonist

Front 59

Alpha-Methyldopa
-Mechanism

Back 59

Alpha-2 agonists, decreases central adrenergic outflow

Front 60

Cocaine
-Mechanism

Back 60

Indirect general agonists, uptake inhibitor

Front 61

Amphetamine
-mechanism

Back 61

Indirect general agonist, release stored catecholamines

Front 62

Ephedrine
-Mechanism

Back 62

Indirect general agonist, release stored catecholamines