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99 Cards in this Set

  • Front
  • Back

Chlorpromazine

Typical Anti psychotic


Phentothiazine Derivative


D2>5-HT2A



Thioridazine

Typical Anti psychotic


Phentothiazine Derivative


D2>5-HT2A

Triflouperazine

Typical Anti psychotic


Phentothiazine Derivative


D2>5-HT2A

Perphenazine

Typical Anti psychotic


Phentothiazine Derivative


D2>5-HT2A

Fluphenazine

Typical Anti psychotic


Phentothiazine Derivative


D2>5-HT2A

Thiothixene

Typical Anti psychotic


Thioxanthene Derivative


D2>5-HT2A

Chlorprothixene

Typical Anti psychotic


Thioxanthene Derivative


D2>5-HT2A

Haloperidol

Typical Anti psychotic


Butyrophenone Derivative


D2>5-HT2A

Droperidol

Typical Anti psychotic


Butyrophenone Derivative


D2>5-HT2A



Spiroperidol

Typical Anti psychotic


Butyrophenone Derivative


D2>5-HT2A

Pimozide

Typical Anti psychotic


Miscellaneous Derivative


D2>5-HT2A

Molindone

Typical Anti psychotic


Miscellaneous Derivative


D2>5-HT2A

Clozapine

Atypical Anti psychotic


Agranulocytosis


D4=Alpha-1>5HT2A>D2=D1

Risperidone

Atypical Anti psychotic


D2=5HT2A


Not as effective

Olanzapine

Atypical Anti psychotic


5HT2A>H1>D4>D2>Alpha-1>D1


Weight gain

Quetiapine

Atypical Anti psychotic


H1>Alpha-1>D2>5-HT2A

Ziprasidone

Atypical Anti psychotic


5-HT2A=D2


Cardiac problems

Aripiprazole

Atypical Anti psychotic


D2=5-HT2A>D4>Alpha-1=H1>>D1


Partial Agonist

Asenapine

Atypical Anti psychotic


D2=5-HT2A


Sublingual

Lurasidone

Atypical Anti psychotic


D2=5-HT2A=5-HT7

Levodopa (L-DOPA)

Parkinson's Treatment


Carbidopa


Effects


- Nausea


- Heart issues


- Behavorial


Limitations


- Loss of response


-Involuntary movements


-Freezing episodes


-On-off fluctuations

Selegiline

Parkinson's Treatment


MAO-B inhibitor


Prolongs effect of L-DOPA

Rasagiline

Parkinson's Treatment


Selective, inhibitor MAO-B inhibitor


Used early on, later with L-DOPA

Tolcapone

Parkinson's Treatment


Selective COMT inhibitor


Inhibits L-DOPA metabolism outside of the brain


Hepatic injury and liver failure

Entacapone

Parkinson's Treatment


Inhibits L-DOPA metabolism outside of brain


No hepatoxicity

Bromocriptine

Parkinson's Treatment


D2 Selective Agonist


Used with long term DOPA


Side effects similar to L-DOPA

Pergolide

Parkinson's Treatment


D1 and D2 agonist


Similar to L-DOPA


Heart valve damage

Pramipexole

Parkinson's Treatment


D2 Agonist


Non-ergot


Used in restless legs syndrome

Ropinirole

Parkinson's Treatment


D2 Agonist


Non-ergot


Used in restless legs syndrome

Rotigotine

Parkinson's Treatment


D3/D2/D1 Agonist


Non-ergot


Transdermal

Anticholinergic Drugs

Benzotropine mesylate


Trihexyphenidyl


Procyclidine


Diphenhydramine


Blocks effects of ACh restoring balance of DA and ACh


Early stages

Amantadine

Antiviral


Increases DA synthesis


Worse than L-DOPA but better than ACh


Early on

Nitrous Oxide

General Anesthetic


Low potency


Low solubility


Gas

Cyclopropane

General Anesthetic


Gas


High potency


Cardiac problems

Diethyl ether

General Anesthetic


Liquid


Potent

Halothane

General Anesthetic


Liquid


Potent


Corrosive


Can't really use with epinephrine


Hepatoxicity

Methoxyflurane

General Anesthetic


Liquid


Most potent


Labor

Enflurane

General Anesthetic


Liquid


Dissolves rubber

Isoflurane

General Anesthetic


Liquid


Most extensively used

Desflurane

General Anesthetic


Liquid

Sevoflurane

General Anesthetic


Liquid

Methohexital Sodium

General Anesthetic


IV


Barbiturate


Poor analgesic


Little Muscle Relaxation


Cardio Effects


Respiratory Effects


Used before analgesics

Thiopental sodium

General Anesthetic


IV


Barbiturate


Poor analgesic


Little Muscle Relaxation


Cardio Effects


Respiratory Effects


Used before analgesics

Opioids used as anesthetics

Fentanyl


Alfentanil


Sufentanil


Remifentanil


IV


Extremely potent

Ketamine

General Anesthetic


IV


Trance like state


No muscle relaxation


Hallucinations

Propofol

General Anesthetic


IV


New widely used

Tricyclic Drugs (10 of them)

Immediately A Tough Dreamy Dancer Neutralized Paranoid Clean Action Men


Imipramine


Amitriptyline


Trimipramine


Doxepin


Desipramine


Nortriptyline


Protriptyline


Clomipramine


Amoxapine


Maprotiline

Trazodone

Atypical Second Generation Antidepressant


5-HT2A Blocker


Sedative


Priapism



Nefazodone

Atypical Second Generation Antidepressant


5-HT2A Blocker


Hepatoxicity

Mirtazapine

Atypical Second Generation Antidepressant


Alpha-2 Adrenergic Blocker among others


Minor side effects


Agranulocystosis

Bupropion

Atypical Second Generation Antidepressants


Smoking cessation


Mechanism uncertain


Seizures

SSRI's (9 of them)

For Sam's Pie Fred Vacuumed Dirty Closets Every Day


Fluoxetine


Sertraline


Paroxetine


Fluvoxamine


Venlafaxine


Desvenlafaxine


Citalopram


Escitalopram


Duloxetine

MAO inhibitors

Antidepressants


Tranylcypromine


Phenelzine


Isocarboxazid


Tyramine food sensitivity

Lithium Salts

Used to treat bipolar disorder


Stabilizes mood


Lithium toxicity

Valproic Acid

Anticonvulsant/Bipolar


Absence, Generalized, Partial


Prolongs Recovery Time of Na+ Channels


Inhibits GABA-transaminase

Lamotrigine

Anticonvulsant/Bipolar


All three seizure types


Blocks Na+ Channels


Combination


Skin Rash

Morphine

Opioid


Receptor Agonist


Basic Structure

Codeine

Opioid


Receptor Agonist


Not as potent


Anti-tussive

Hydromorphone

Opioid


Receptor Agonist


More potent

Heroin

Opioid


Receptor Agonist

Hydrocodone

Opioid


Receptor Agonist

Oxycodone

Opioid


Receptor agonist


Combined with tylenol to form percocet

Oxymorphone

Opioid


Receptor agonist



Pantopium

Opioid


Receptor agonist

Merperidine

Opioid


Receptor agonist


Less constipation

Fentanyl

Opioid


Receptor agonist


Very potent


Used in combination with other drugs

Diphenoxylate

"Opioid"

Used to treat diarrhea




Loperamide

"Opioid"


Used to treat diarrhea

Methadone

Opioid


Similar to morphine, higher efficacy and extended duration of action

Propoxyphene

Opioid


Overdose common

Dextromethorphan

Anti-tussive

Naloxone

Opioid antagonist


Reverses opioid effects

Naltrexone

Opioid antagonist


More potent than naloxone

Buprenorphine

Opioid partial agonist


Used as maintenance drug with naloxone

Cocaine

Local Anesthetic


Ester


Vasoconstriction


Pupil dilation


Sensitization to all catecholamine effects

Ethyl aminobenzoate (Benzocaine)

Local Anesthetic


Ester


Topical

Procaine

Local Anesthetic


Ester


Infiltration

Tetracaine

Local Anesthetic


Ester


Toxicity greater


Spinal Anesthesia

Lidocaine

Local Anesthetic


Amide


Potent, versatile, widely used

Mepivacaine

Local Anesthetic


Amide


Longer acting


Infiltration and spinal

Dibucaine

Local Anesthetic


Amide


Long acting, toxic


Topical

Bupivacaine

Local Anesthetic


Amide


Longer acting

Phenytoin

Anticonvulsant


Hydantoin


Partial and Generalized

Mephenytoin

Anticonvulsant


Hydantoin


Partial and generalized


Toxic, hepatitis, skin falls off

Ethotoin

Anticonvulsant


Hydantoin


Partial and generalized


Less toxic, less efficacious


Sedation

Phenobarbital

Anticonvulsant


Barbiturate


Partial and generalized


Widely used


Sedative effect, hyperactivity in children, confusion in elderly


Liver interactions

Mephobarbital

Anticonvulsant


Barbiturate


Generalized and partial Seizures


Toxicity and uses same as phenobarbital

Primidone

Anticonvulsant


Deoxybarbiturate


Generalized and partial


Sedation, dizziness, nausea, vomiting


Combine with other drugs

Carbamazepine

Anticonvulsant/Bipolar


Iminostilbene


Partial and Generalized


Similar to phenytoin


Reducing Na+ channel function


Ataxia, vertigo, blurred vision, nausea, bone marrow depression



Oxcarbazepine

Anticonvulsant


Partial Seizures


Dizziness, nausea, vomiting

Eslicarbazepine acetate

Anticonvulsant


Partial Seizures


Recovery of Na+ channels

Gabapentin

Anticonvulsant


Gaba Agonist


Combination

Felbamate

Anticonvulsant


Partial and generalized


Quickly redrawn


Many risks

Topiramate

Anticonvulsant


Partial and Generalized


Blocks Na+ Channels

Tiagabine

Anticonvulsant


Partial


GABA uptake blocker

Zonisamide

Anticonvulsant


Partial and generalized
Blockade of Na+ channels

Ethosuximide

Anticonvulsant


Absence


Effect, least toxic


Inhibiting Ca2+ currents in thalamic neurons

Clonazepam

Anticonvulsant


Absence


Not used much

Diazepam

Anticonvulsant