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26 Cards in this Set
- Front
- Back
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alpha-1 receptor
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Gq/11, IP3
Constricts blood vessels |
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alpha-2 receptor
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Gi, lowers cAMP
constricts blood vessels presynaptic transmitter release |
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beta-1 receptor
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Gs, increases cAMP
increases heart rate and force |
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beta-2 receptor
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Gs, increases cAMP
relaxes gut, blood vessels and bronchioles |
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alpha-methyltyrosine
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Inhibits Tyrosine hydroxylase
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Carbidopa
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Inhibits DOPA decarboxylase
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Disulfiram
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Inhibits D-beta hydroxylase
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Iproniazid
Tranylcypromine |
Non Specific MAO inhibitors
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Clorgyline
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MAO-A inhibitor
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Selegiline
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MAO-B inhibitor
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Entacapone
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COMT inhibitor
Parkinson's |
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Uptake 1
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Neuronal, high affinity.
Inibited by imipamine, cocaine |
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Uptake 2
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Non neuronal, low affinity
Inhibited by corticosteriods |
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Adrenaline
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α>β
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Noradrenaline
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α>β1>β2
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Phenylephidrine
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α1 agonist
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Clonidine
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α2 agonist
Hypertension, lowers presynaptic transmitter release |
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Methylnoradrenaline
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False transmitter, α2 agonist. Lowers vasoconstriction
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Labetalol
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Mixed α1 and β antagonist
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Dobutamine
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β1 agonist, positive ionotropic effect
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Salbutamol
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β2 agonist, bronchodilate
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Prazosin
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α1 antagonist
Vasodilatation |
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Yohimbine
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α2 antagonist
Reverse actions of clonidine |
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Propranolol
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Mixed β antagonist
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Atenolol
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β1 antagonist, heart failure and dysrhythmmias
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Butoxamine
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β2 antagonist
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