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36 Cards in this Set

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A1 adrenergic receptor

order of catecholamine potency
Ne >= Epi >> Iso
A2 adrenergic receptor

order of catecholamine potency
Epi >= NE >> Iso
A1 adrenergic receptor agonist
phenylephrine
methoxamine
phenylephrine

methoxamine
A1 adrenergic receptor agonist
A2 adrenergic receptor agonist
clonidine
brimonidine
clonidine
brimonidine
A2 adrenergic receptor agonist
A1 adrenergic receptor antagonist
prazosin
terazosin
prazosin
terazosin
A1 adrenergic receptor antagonist
A2 adrenergic receptor antagonist
yohimbine
yohimbine
A1 adrenergic receptor antagonist
A1 receptor location
- SMOOTH MUSCLE
- salivary and sweat glands
- liver
A1 receptor responses
- SMOOTH MUSCLE - contraction
- salivary and sweat glands - K+ release/secretion
- liver - K+ release
A2 receptor location
- vascular smooth muscle
- Pancreatic B-cells
- platelets
- presynaptic terminal
A2 receptor responses
- vascular smooth muscle - contraction
- Pancreatic B-cells - decreased insulin secretion
- platelets - aggregation
- presynaptic terminal - decreases adrenergic release (feedback inhibition)
B1 adrenergic receptor

order of catecholamine potency
Iso > Epi = NE
B2 adrenergic receptor

order of catecholamine potency
Iso > Epi >> NE
B1 adrenergic receptor

agonist
dobutamine
dobutamine
B1 adrenergic receptor

agonist
B2 adrenergic receptor

agonist
albuterol
ritodrine
salmeterol
albuterol
ritodrine
salmeterol
B2 adrenergic receptor

agonist
B1 adrenergic receptor

antagonist
metoprolol
metoprolol
B1 adrenergic receptor

antagonist
B1 and B2 adrenergic receptor

antagonist
propranolol
timolol
propranolol
timolol
B1 and B2 adrenergic receptor

antagonist
B3 adrenergic receptor

order of catecholamine potency
Iso = NE > Epi
B1 adrenergic receptor locations
- HEART
- J-G cells
B1 adrenergic receptor responses
- HEART - increased rate, force, conduction and velocity
- J-G cells - increased renin release
B2 adrenergic receptor locations
- Smooth muscle (vascular, GU, resp)
- skeletal muscle
- liver
- mast cells
B2 adrenergic receptor responses
- Smooth muscle (vascular, GU, resp) -- relaxation/vasodilation
- skeletal muscle - tremor, glycogenolysis
- liver - gluconeogenesis
- mast cells - decreases mast cell release
B3 adrenergic receptor location/responses
- located in adipose tissue -- lipolysis
NE active at which receptors?
A1, A2, B2
Epi active at which receptors?
A1, A2, B1, B2
Iso active at which receptors?
B1, B2
DA active at which receptors?
D1, B1

dopaminergic neurons of the kidey --> vasodilation of the renal beds
Do (doputamine) active at which receptors?
B1
Affect of Epi on the SA node?
Increases Ica (slow inward) --> increases outward Ik --> increases pacemaker If

increased rate or rise, amplitude

decreased delay between beats (faster repolarizaion) --> increase HR