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48 Cards in this Set
- Front
- Back
List the SNS neurotransmitters
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NE, 5HT, DA,
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List excitatory messengers
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SNS neurotransmitters (NE, DA, 5HT)
CNS neurotransmitters: glutamate, NMDA Hormones: Epi Polypeptides: CCK, Substance P, Neuropeptide Y Opiods: Beta endorphins, Enkephalins, Dinorphins Endocannaboids |
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MAO's vs Catecholamines
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MAO's= 5HT, NE, DA "SND"
catecholamines= Epi, NE, DA "END" |
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COMT inh
MOA: uses: S/E: |
MOA: inh COMT from breaking down catecholamenis "END" in the postganglion
uses: Parkinsons S/E: ??? |
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List 5HT agonists
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1) Cisapride
2) Methysergide 3) Metachlopromide 4) Sumatriptan |
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Cisapride
MOA: uses: S/E: |
MOA: 5HT agonist
uses: GERD, delayed gastric emptying (seen in DM, post surgery) S/E: Torsades, blocks p450 ****pulled off market |
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Methysergide
MOA: uses: S/E: |
MOA: 5HT agonist
uses: migraines S/E: MI, strokes, retroperitineal fibrosis *****pulled off market |
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Metachlopramide
MOA: uses: S/E: |
MOA: 5HT agonist, DA blocker
uses: GERD, Delayed gastric emptying (seen in DM and post surgery) S/E: Parkinsons- like sx's *****pulled off market |
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Sumatriptan
MOA: uses: S/E: CI: |
MOA: 5HT agonist
uses: DOC for migraines S/E: coronary vasospasm CI: CADz, Prinzmetels angina, preg |
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alpha 2 rec locations and stimulation
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1) CNS: dec sympathetics
2) beta cells: dec insulin secretion |
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dynamics of
1) Epi 2) NE 3) DA |
1) Epi: beta > alpha (low doses)
alpha > beta (high doses) 2) NE: alpha1, 2 > beta 1 (does not de beta 2) 3) DA: D2 at low dose (perfuse kidney) Beta 1 at med dose (inc contractility) alpha 1 at high dose (vasoconstrict) *reverse from alphabetical order, D-->B-->A |
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rec and 2nd messenger for
1) alpha 1 2) alpha 2 3) beta 1 4) beta 2 5) D1 6) D2 |
1) Gq: IP3/DAG
2) Gi: dec cAMP 3) Gs: inc cAMP 4) Gs: inc cAMP 5) Gs: inc cAMP 6) Gi: dec cAMP |
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locations and stimulation of alpha 1 rec
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1) sphincter: tighten
2) arteries/veins : constrict 3) eye radial musc: mydriasis w/o cycloplegia |
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Epi
uses: clue: |
uses: DOC for anaphylaxis and DOC for Vfib
clue: short 1/2 life (2hrs), bad rebound |
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Which drug causes rhinitis medicamentosa?
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Epi
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NE:
uses: |
uses: DOC for septic shock
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DA
uses Dobutamine uses |
????
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name 2 alpha 1 agonists
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1) Pseudoephedrine
2) Phenylephrine |
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Phenylephrine
MOA: uses: |
MOA: alpha 1 agonist
uses: decongestion, DOC for neurogenic shock |
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Name 4 alpha 1 blockers
uses S/E: |
1) Parazosin- HTN only
2) Terazosin- bph 1st line 3) Doxazosin- bph 1st line` 4) Tamsusolin- bph 2nd line S/E: 1st dose hypOtension |
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DOC for BPH
MOA: 2nd line for BPH MOA |
DOC: Terazosin and Doxazosin
MOA: alpha 1 blocker 2nd line: Tamsusolin MOA: alpha 1 blocker |
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Parazosin
MOA uses S/E: |
MOA: alpha 1 blocker
uses: HTN S/E: 1st dose syncope (take at night) |
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Name 3 alpha 2 agonists
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1) Clonidine
2) alpha methyldopa 3) guanabenz |
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Clonidine
MOA uses S/E |
MOA: alpah 2 agonist (alpha 2 rec only found in CNS- thats why it drops BP)
uses: HTN, tourettes, menopause sx's S/E: rebound HTN if stopped quickly |
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alpha methyldopa
MOA: uses: S/E: |
MOA: alpha 2 agonist (alpha 2 rec only see in CNS- thats why it drops BP)
uses: DOC for HTN in preggos S/E: hemolytic anemia, rebound HTN if stopped quickly |
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Name 3 alpha 2 blockers
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1) Yohimbine
2) Mirtazapine 3) Tolazoline |
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Yohimbine
MOA: uses: |
MOA: alpha 2 blocker
uses: impotence (allows you to "shoot") |
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Mirtazapine
MOA uses: |
MOA: alpha 2 blocker
uses: depression S/E: sedation, inc cholesterol, inc appetite |
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Tolazoline
MOA: uses: |
MOA: alpha 2 blocker
uses: RDS in premies |
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Name 2 nonselective alpha blockers
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phentolamine, phenoxybenzine,
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Epi/NE reversal
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nonselective alpha blockers
(phentolamine, phenoxybenzine) |
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Phentolamine
MOA: uses: |
MOA: nonselective alpha blocker; short acting
uses: dx pheo, HTN in cocaine users |
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Phenoxybenzamine
MOA: uses: |
MOA: nonselective alpha blocker; long acting
uses: rx carcinoid, rx pheochromocytoma |
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Dobutamine
MOA: uses: effects on HR, contractility, BP |
MOA: beta-1 agonist
****the only one uses: cardiogenic shock, CHF inc HR, inc contractility, no affect on BP |
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Name the Beta 2 agonists
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1) Formoterol
2) Albuterol 3) Ritodrine 4) Terbutaline 5) Salmeterol "FARTS" |
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Name the 3 nonselective beta agonists
(which still have a little more beta 2 affinity than beta 1) |
1) Metaproteronol
2) Isoproteronol 3) Levoproteronol "MIL" |
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Name the 3 beta-nonselective blockers
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1) Timolol
2) Prapanolol 3) Nadolol "TPN" "N-Z, C&L" |
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Which beta rec working drugs can be used to bronchodilate?
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1) Formoterol- beta 2 agonist
2) Albuterol- beta 2 agonist 3) Terbutaline- beta 2 agonist 4) Salmeterol- beta 2 agonist 5) metaproterenol- ns beta agonist F and S are long lasting (BID) |
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which beta rec working drugs can be used to treat glaucoma?
How do they help? |
1) butexolol- beta 1 blocker
2) timolol- ns beta blocker 3) nadolol- ns beta blocker -dec production of aqueous humor |
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Which beta rec working drugs can be used to delay preterm labor?
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1) Ritodrine- beta 2 agonists
2) Terbutaline- beta 2 agonists |
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Which beta rec working drug do we use to treat thyroid storm?
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Esmolol- short acting beta 1 blocker
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Labetalol
MOA uses |
MOA: blocks alpha1, beta 1, beta 2 equally
"a nonselective beta blocker that also blocks alpha 1" uses: Afib, HTN crisis (preggo, dissection, pheo) |
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Carvedilol
MOA uses |
MOA: blocks alpha 1, beta 1, beta 2 equally
"a non-selective beta that also blocks alpha 1" uses: HTN crisis (preggos, dissection, pheo), chronic CHF |
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Name 2 drugs that release stored catecholamineds
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1) Amphetamines
2) Ephedrine |
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Amphetamine
MOA uses |
MOA: releases stored catecholamines
uses: obesity, ADHD, narcolepsy |
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Ephedrine
MOA uses |
MOA: releases stored catecholamines
uses: decongestant, urinary incontinence, hypOtension |
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Cocaine
MOA uses |
MOA: catecholamine uptake inh
uses: nose surgeries |
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DOC for stress incontinince
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Pseudoephedrine
(alpha 1 agonist) |