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146 Cards in this Set

  • Front
  • Back
In which type of dog breed is AA subluxation most common?
Small breeds.
Trauma can cause what type of injury to the Atlas or Axis?
Rupture of the transverse ligament of the axis or fracture of the dens.
AA subluxation causes clinical signs of transverse myelopathy at what level?
C1-C5.
What is a classic radiographic sign of AA subluxation?
Hyperflexion of C1-C2.
What is a general definition of calcinosis circumscripta?
Calcium deposits in the periarticular tissues (can get cord compression).
Which dog breed is predisposed to calcinosis circumscripta?
German Shepherd Dogs.
Wobblers is common term for what condition?
Caudal Cervical spondylomyelopathy.
Great Danes with Wobbler’s have dorsal compression due to what?
Elongation of the cranial dorsal arch.
What age of Great Dane are affected with Wobbler’s?
Less than 2 years. (Dobie’s are 3-9 years).
At what location is the pathology of caudal cervical spondylomyelopathy in Doberman Pinschers?
Centered over the annulus of a disc.
Instability of Wobbler’s causes what secondary condition?
Osteoarthrosis.
In a case of Wobbler’s what can be seen radiographically on the craniovertebral body?
Exostosis.
Which type of congenital vertebral abnormality most likely results in cord compression?
Hemivertebrae.
How many criteria are necessary to diagnose Disseminated Idiopathic Skeletal Hyperostoses?
Four.
What are the criteria of DISH?
1. Flowing calcification along the ventral and lateral aspects of three contiguous vertebrae (maybe four). 2. Preservation of IVD width. 3. Periarticular osteophytes surrounding the true vertebral joints. 4. Pseudoarthrosis around bases of spinous processes. 5. Osteophytes and enthesophytes at soft tissue attachments in the skeleton.
What is myelodyplasia?
Malformations from incomplete closure or abnormal development of the spinal cord.
Is which dog breed is myelodysplasia inherited?
Weimaraners.
Failure of fusion of the vertebral arches +/- protrusion or dysplasia of the meninges and cord is termed what?
Spina Bifida.
What is Spina Bifida occulta?
Normal spinal cord and meninges but abnormal vertebrae.
In which condition is the neuroectoderm contiguous with the skin?
Spina bifida with Myelorhachischisis.
What is the most common location of the spina bifida?
Caudal lumbar.
Which of the dog and cats breeds are bredisposed to spina bifida?
English bulldog and Manx cat.
What is an intraarachnoid cyst?
Accumulation of the CSF anywhere in the CNS.
What is another term for multiple cartilaginous exostoses?
Osteochondromatosis.
Osteochondromatosis in cats is believed to have what type of cause?
Infectious-viral.
Where are osteochondromatosis lesions typically seen?
On the thoracolumbar spine.
Which disease in cats is a defect in the metabolism of GAGs?
Mucopolysaccharoidosis.
In which type of cats does mucopolysaccharoidosis cause skeletal changes which can lead to cord compression?
Siamese.
What are some characteristic deformities of a cat with mucopolysaccharoidosis?
Small head. Flat face. Wide eyes. Large paws.
What is a pilonidal sinus?
Invagination of the skin dorsal to the spine that can extend down as far as the dura and can communicate with the subarachnoid space.
What is the cause of a pilonidal sinus?
Failure of separation of the neural groove from the epidermis.
Which dog breed is the classic representation of a pilonidal sinus?
Rhodesian Ridgeback (but not necessarily at the ridge).
What is a dermoid cyst?
A teratoma with hair and sebum.
What lysosomal storage disease causes symmetrical white matter demyelination of the brain?
Globoid cell leukodystophy.
What is the most common site of cervical vertebral myelopathy?
C3-C4.
What is the common location of IVDD in dogs?
T11-L3.
Why is IVDD rare in dogs from T1 through T11?
Intercapital ligaments stabilize the discs.
Type I IVDD is associated with what type of disc degeneration?
Chondroid disc degeneration (degeneration of the annulus fibrosis).
In chondrodystrophic breeds the nucleus of all IV discs have become cartilage by what age?
1 year.
What is the description of a Type II IVDD?
Bulging of the disc without rupture of the annulus fibrosis.
What is the type of disc degeneration associated with a Type II IVDD?
Fibroid degeneration.
What is the direction of rupture of a Type II disc?
Dorsolateral.
What percentage of IVDD dogs walk again when there is no T2 hyperintensity on MRI?
100%.
If T2 hyperintensity extends beyond three times the length of L2 what is the percentage of those dogs walk again?
20% (in this study dogs with any T2 hyperintensity of any sort were less likely to walk).
Why is progressive haemorrhagic myelomalacia fatal?
Respiratory paralysis.
Radiographically what type of defect is seen at the LS with LS vertebral canal stenosis?
A step defect.
In which dog breed is LS vertebral canal stenosis usually seen?
German Shepherd Dog (between 3 and 7 years).
What is the cause of degenerative myelopathy?
Demyelination and axonal degeneration. Astrocytosis of the cord white matter. (Again German Shepherd Dogs. Plus Corgis and Boxers).
At what level of the spinal cord does degenerative myelopathy usually occur?
Thoracic spinal cord.
What type of cyst can arise from the articular facets of the cervical and thoracolumbar region of dogs?
Synovial cysts (because they are diarthrodial joints).
Define Hydromyelia?
Dilation of the central canal.
What is term for cavitation of the spinal cord?
Syringomyelia.
T/F. Dural ossification is very common and rarely a problem.?
True.
What is the term for osteophytes at the vertebral endplates?
Spondylosis deformans.
The caudal equina is made up of nerve roots of which verterbrae?
L7. S1 through 3. Caudal 1-5.
How would you characterize the clinical presentation of an FCE?
Acute onset. Lacks progression after several hours. Non-painful. Often a history of exercise.
What is a differential diagnosis for an intradural extramedullary tumor of a young dog of the spinal cord?
A nephroblastoma.
What is a common location for malignant nerve sheath tumor?
The brachial plexus.
What structures are affected by discospondylitis?
The intervertebral disc and associated vertebral body (spondylitis is vertebra only).
What is the most common route of infection of discospondylitis?
Hematogenous (associated with UTI-Endocarditis-and dental disease).
At what level do migrating foxtails cause discospondylitis?
L2 to L4.
What is the most common zoonotic organism associated with discospondylitis?
Brucellosis.
What is the term for inflammatory cells in the leptomeninges?
Meningitis.
Define myelitis?
Inflammatory cells and necrosis of the cord.
A dog with meningomyelitis may present with what type of stance?
Saw horse stance.
What is the differential diagnosis for perivascular accumulations of mononuclear cells in the brain and spinal cord of unknown cause?
Granulomatous meningoencephalomyelitis.
What is the likely cause of meningitis and myelitis in a cat with FIP?
Immune-complex mediated vasculitis.
What type of change does distemper virus cause in a dog with distemper myelitis?
Demyelination of grey and white matter.
What is an often seen clinical sign of distemper myelitis?
Myoclonus of any muscle.
What type of protozoal myelitis might be seen in a dog or a cat from eating infected meat?
Toxoplasma (also transmitted via cat feces or transplacental).
In which type of dog might you see steroid responsive meningitis arteritis?
In a young dog. Medium to large breed.
From which embryonic layer is the nervous system derived?
The ectoderm from the trilaminar germ layers (ecto>meso>endo).
The pia and arachnoid mater are neural crest in origin; what is the origin of the dura mater?
Mesenchymal.
What is myeloschisis?
Severe spina bifida. The cord ends up exposed to the external environment.
From which nervous system components do the vertebral bodies form?
Sclerotomes.
Abnormalities in which portion of the axis result in an AA lux?
The proatlas and the centrum 1.
Which cells produce CSF?
Ependymal cells of the ventricular system and the choroid plexus.
What is the flow of CSF through the ventricles?
Lateral ventricular>interventricular foramen>third ventricle> mesencephalic aqueduct> fourth ventricle> lateral apertures> central canal and subarachnoid space.
Which cells of the brain have the highest demand for oxygen?
Neurons> oligodendroctyes-astrocytes-microglia> fibrovascular cells.
In the case of an infarction in the brain Macrophages will fill in the necrotic area and creates a scar; what is the resultant region called?
Neurogliosis.
What is the term for thrombosis or embolus of an artery or thrombus of venous drainage?
Infarction.
Infarction from septic emboli may be associated with what other condition?
Endocarditis.
What is the distribution of a lesion with idiopathic cerebral infarction?
The distribution of the middle cerebral artery (cats without cardiomyopathy).
Which MRI pulse sequence is very sensitive for cytotoxic edema?
DWI.
What is the common appearance of an infarct of the cerebellum?
Wedge shaped and well defined (hyper on T2 and hypo or iso on T1).
What dog breed is overrepresented for infarction of the cerebellum?
Cavalier King Charles Spaniel.
With brain hemorrhage in what time frame does clot expansion usually occur?
First 6 hours.
What is the age of haemorrhage if it appears hypointense on T1?
Hyper acute (<24 hours) or acute (1-3 days).
What is the age of haemorrhage if it appears hypointense on T1 and hypointense on T2?
Acute (1-3 days).
What is the age of haemorrhage if it appears hyperintense on T1 ad T2?
Late subacute (7-30 days).
What hemoglobin breakdown product causes the mri appearances in acute haemorrhage?
Deoxyhemoglobin.
What hemoglobin breakdown product causes the mri appearances in chronic haemorrhage > 30 days?
Hemosiderin.
In the case of haemorrhage of the brain are the Houndsfield units increased or decreased for the first week following?
Increased (hyperattenuating).
On CT is a brain haemorrhage contrast enhancing or non contrast enhancing?
Non contrast enhancing.
What are the common locations for obstructive hydrocephalus?
The interventricular foramen and mesencephalic acqueduct.
What is the definition of communicating hydrocephalus?
Non- obstructive but dilation of the entire system.
Which dog breed types are predisposed to congenital hydrocephalus?
Toys and brachys.
In which anatomic location of the brain is it common to see an accumulation of CSF whether incidental or compressive?
Quadrigeminal cistern.
What is thought to be the cause of Chiari-like malformation?
Small caudal fossa.
What clinical signs are seen with Chiari-like malformation?
Scratching at neck. Flybiting seizures. Brain or cervical signs.
What type of cells die prematurely causing cerebellar abiotrophy?
Purkinje cells.
What are the MRI findings of the brain with Portosystemic shunt?
Widened sulci and grey matter atrophy. Hyperintense foci in the lentiform nuclei on T1 (possibly due to manganese accumulation).
What is the cause of multiple system degeneration of the brain?

Degeneration of the basal ganglia and the caudate nucleus and cerebellum.

What is the clinical signs of multiple system degeneration of the brain?

Cannot initiate movement and maintain balance.

Which dogs are predisposed to multiple system degeneration of the brain?

Kerry blue terriers and Chinese crested.

What are other names for paraoxysmal dyskinesis?
Scottie Cramp or Dancing Doberman disease (episodes of voluntary movement and not seizures defined by EEG).
In which type of dogs are idiopathic tremors usually seen?
White small breed dogs (Westies and Maltese).
In which condition especially in Lhasa Apsos is the brain smoothed and thickened?
Lissencephaly.
What condition can be caused with a uterine infection by panleukopenia virus in the cat?
Cerebellar hypoplasia (also canine parvovirus and Dandy Walker in humans).
What are the most common viral causes of encephalitis?
Distemper and FIP.
Viral encephalitis causes what two types of damage to the brain?
Cytotoxic and immune-mediated.
In a dog with distemper what other systemic clinical signs are seen with the neurologic signs and are useful for diagnosis?
Respiratory and GI signs may be prior or concurrent. Pad and nasal planum changes are often concurrent.
What form of the FIP is associated with encephalitis?
The non-effusive form.
What MRI finding may be seen on FIP encephalitis?
Periventricular contrast enhancement.
What are the common bacterial organisms that cause encephalitis?
Staph and strep and Klebsiella and E.coli.
What are classic clinical signs of a bacterial encephalitis?
Fever and cervical hyperesthesia.
What is the most common cause of fungal encephalitis?
Cryptococcus.
What are common MRI findings with fungal encephalitis?
Strongly contrast enhancing intraaxial lesions (Fungal granulomas often have significant perilesional edema).
What is another term for necrotizing meningoencephalitis?
Pug dog encephalitis.
What type of lesions are seen with necrotizing meningoencephalitis?
Asymmetrical cavitary necrosis and inflammation of white and grey matter.
What is the suspected cause of necrotizing meningoencephalitis?
Auto-immune.
What are the cytologic findings with necrotizing meningoencephalitis?
Lymphocytes.
What is another term for Yorshire Terrier Encephalitis?
Necrotizing leukoencephalitis (lymphocytes and mononuclear cells).
What are the MRI findings with pug or yorkie encephalitis?
Mulifocal ill-defined hypo T1- hyperT2- inconsistently enhancing lesions.
T/F. GME is common in cats.?

False.

What are three forms of GME in the dog?
Focal and Multifocal (most common) and Ocular (rare).
Are GME lesions more common in white or grey matter?
White.
What is the common signalment of a dog with GME?
Middle aged female small breed dog.
What percentage of cats with neuro disorders have inflammatory or infectious neurodisease?
32%.
What is the most common brain tumor in dogs and cats?
Meningioma.
Meningioma is what type of tumor (cellular)?
Mesenchymal.
Meningioma is often associated with what change of the overlying bone?
Hyperostosis.
What are the MRI findings of meningioma?
T2 hyperintensity; T1 isointensity and strongly contrast enhancing; has a dural tail.
What is the second most common brain tumor in dogs?
Glioma (fourth in cats).
What is the most common location of a choroid plexus tumor?
Lateral ventricle or the fourth ventricle.
Which breed is overrepresented for choroid plexus tumor?
The Golden retriever.
What are the MRI findings of a choroid plexus tumor?
T1 iso to hyper; T2 hyper; strong contrast enhancing.
What is the common location for ependymoma in the dog?
The lateral ventricles (in the cat: third and lateral ventricles).
What is the most secondary tumor in dogs and cats?
The lymphoma.
What are the MR findings of LSA?
Strongly homogenously enhancing with peritumoral edema.
In what percentage of cases of PDH are macroadenomas found?
10-30%.
In one study which was more common primary or secondary brain tumors?
Secondary brain tumors.
What is the most common cause of vestibular disease in dogs and cats?
Middle and inner ear infection.
What are the common organisms that cause middle and inner ear infections?
Staph and Strep and Proteus.
What condition in cats originates from the auditory tube or nasopharynx or middle ear and causes respiratory and vestibular disease?
Nasopharyngeal polyps.
Infection of the inner or middle ear or the guttural pouch can cause what condition of the hyoid bone in the horse?
Temporohyoid osteopathy.