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14 Cards in this Set
- Front
- Back
PCN
|
-cidal
time dependent |
|
cephalosporins
|
-cidal
time-dependent |
|
carbapenems
|
-cidal
time dependent |
|
monobactams
|
-cidal
time dependent |
|
macrolides
|
-static
debate over concentration dependent or time dependent (due to pt intolerance, they are dosed in a manor that makes them time dependent) |
|
lincosamides
|
can be -cidal or -static, depending on organism, inoculum, drug concentration
(likely static against S. aureus) debate over concentration dependent or time dependent (due to pt intolerance, they are dosed in a manor that makes them time dependent) |
|
sulfonamides
|
bacteriostatic
time-dependent killing |
|
fluoroquinolones
|
rapidly bactericidal
concentration-dependent |
|
aminoglycosides
|
rapidly bactericidal
concentration-dependent |
|
glycopeptides
|
(vancomycin)
can be static or cidal (depends on the distribution to the site of infection, inoculum size, protein-binding, and the organism) **PAE only exists at high concentrations time-dependent, although concentration matters AUC/MIC > 400 associated with best outcomes "concentration-INdependent |
|
lipopeptides
|
(daptomycin)
rapidly bactericidal concentration-dependent |
|
lipo-glycopeptides
|
(telavancin)
rapidly bactericidal concentration-dependent |
|
streptogramins
|
dalfoprisitin/quinupristin
*bactericidal in combination, bacteriostatic alone primarily time dependent (significant PAE for gram + bacteria!!) |
|
oxazolidinone
|
linezolid
static time dependent |