Absite Review Wound Healing

Front 1

what is the first phase of wound healing and how long does it last?

Back 1

Inflammation, days one through 10

Front 2

which cell type has the predominant role during the inflammation phase?

Back 2

Macrophages

Front 3

which is the first cell type to arrived in a wound?

Back 3

platelets

Front 4

which cell type is most abundant during the first two days in a wound?

Back 4

PMN's

Front 5

which cell type is most abundant days three through four in a wound?

Back 5

Macrophages

Front 6

which cell type is most abundant days five and up in a wound?

Back 6

fibroblasts

Front 7

what is the second phase of wound healing, and how long does it last?

Back 7

proliferation, days five through 21

Front 8

what is the predominant cell type during the proliferation phase?

Back 8

Fibroblasts

Front 9

what is the third phase of wound healing? And how long does it last?

Back 9

Remodeling/maturation, days 21 to 1 year

Front 10

when does neovascularization begin?

Back 10

proliferation phase

Front 11

when does collagen production begin?

Back 11

around day seven, during proliferation phase

Front 12

when does collagen production peak?

Back 12

around 21 days

Front 13

which collagen type is predominant in early wound healing?

Back 13

collagen type III

Front 14

what happens to collagen type III during the maturation phase

Back 14

by maturation phase, day 21, collagen type III has been completely replaced by collagen type I

Front 15

when does collagen type I synthesis begin?

Back 15

days 3 through four

Front 16

what is the most common amino acid in collagen?

Back 16

proline

Front 17

which collagen amino acids are required for cross-linking?

Back 17

hydroxy proline,( hydroxylated proline) and hydroxylysine, (hydroxylated lysine)

Front 18

what is required for the hydroxylation of proline?

Back 18

Vitamin C, oxygen, iron, and alpha-ketoglutarate

Front 19

what is the most common type of collagen in the body?

Back 19

Type I, found in skin and bones and tendons

Front 20

where is collagen type II found?

Back 20

cartilage

Front 21

Where is collagen type 4 found?

Back 21

Basement membrane

Front 22

where is collagen type 5 found?

Back 22

cornea

Front 23

how long should we wait before revising a scar?

Back 23

At least one year to allow the scar to mature

Front 24

which type of cell is the last cell to arrive at a wound?

Back 24

lymphocytes

Front 25

what is the main component of the extracellular matrix?

Back 25

Collagen

Front 26

what is the most important factor in wound healing via primary intention?

Back 26

Tensile strength, collagen disposition and cross-linking

Front 27

what is the most important factor in wound healing via secondary intention?

Back 27

Epithelial integrity

Front 28

which cell is involved in wound contraction?

Back 28

Myofibroblasts

Front 29

how can we counteract the negative effects of steroids on wound healing?

Back 29

vitamin A

Front 30

how does radiation affect wound healing?

Back 30

By impairing fibroblasts

Front 31

what is the difference between hypertrophic scars and keloids?

Back 31

collagen in hypertrophic scars are limited to the confines of scar

Front 32

what is the inheritance pattern of keloids

Back 32

autosomal dominant

Front 33

what is the growth factor associated with hypertrophic scars and keloids?

Back 33

TGF-beta

Front 34

what are the treatment options for keloids?

Back 34

Pressure, steroids, silicone, and radiation

Front 35

what is the effect of bacteria on wound healing?

Back 35

Decreasing oxygen content and collagen lysis

Front 36

what bacterial count is considered a wound infection?

Back 36

>10 to the fifth/centimeter squared

Front 37

how do foreign bodies affect wound healing?

Back 37

They retard granulation tissue formation

Front 38

what is the most common cause of leg ulcers?

Back 38

Venous insufficiency

Front 39

what is the role of the nervous system on wound healing?

Back 39

None