Absite Oncology

Front 1

MCC of cancer related death in men or women

Back 1

lung

Front 2

MC CA in men and women

Back 2

breast and prostate

Front 3

T cells vs NK cells

Back 3

former need MHC complex to attack tumor

Front 4

Tumor markers for
Colon CA
Liver CA
Pancreatic CA
testicular CA
ChoriocCA
Prostate

Back 4

CEA
AFP
CA 19-9
CA 125
beta HCG
PSA
BRCA I and II
NSE (small cell lung CA, neuroblastoma)

Front 5

EBV is a/w what ttypes of CA

Back 5

Burkitt's lymphoma
Nasopharyngeal CA (c-myc)
retroviruses contain oncogenes

Front 6

Most vulnerable stage of cell cycle for XRT

Back 6

M phase
target DNA via oxygen radicals

Front 7

Higher energy radiation has what effect

Back 7

skin preservation

Front 8

Fractionate doses

Back 8

allows repair of nl cells, tumor rexoygenation, and redistribution of tumor cells in cell cycle

Front 9

Very radiosensitive tumors

Back 9

seminomas
lymphomas

Front 10

very radioresistant tumors

Back 10

epithelial
sarcomas

Front 11

organs with increased sensitivity to XRT

Back 11

kidneys, lungs, liver, and lymphocytes

Front 12

Cell cycle specific chemo

Back 12

exhibit plateau in cell killing ability

Front 13

Tamoxifen

Back 13

decreases 5 year risk of breast CA by 45%
1% DVT
0.1% endometrial CA

Front 14

MOA of Taxol

Back 14

microtubule formation --> rupture cells

Front 15

which 2 chemo agents cause pulmonary fibrosis

Back 15

bleomycin
busulfan

Front 16

Adverse efx of cisplatin

Back 16

neuro, neuro, ototoxic

Front 17

Adverse efx of carBOplatin and vinBlastine

Back 17

BOne suppression

Front 18

2 microtubule inhibitor chemo agents

Back 18

Vincristine (peripheral neuropathy and neurotoxic)
vinblastine

Front 19

MOA and AE of cyclophosphamide

Back 19

alkylating agent
acrolein is active metabolite
AE SIADH, hemorrhagic cystitis (mesna can help)

Front 20

MTX MOA

Back 20

DHFR inhibitor --> purine
nephrotoxic

Front 21

role of leucovorin

Back 21

reverses effects of MTX by decreasing folate
increases toxicity of 5FU

Front 22

MOA of 5FU

Back 22

inhibits thymidylate synthesis (purine)

Front 23

MOA/AE of doxorubicin

Back 23

DNA intercalater, oxygen radial
cardiotoxic

Front 24

GCSF AE

Back 24

sweet's syndrome (acute febrile neutropenic dermatitis)

Front 25

Name 6 tumor suppressor genes

Back 25

Rb1
p53
APC
DCC
bcl
BRCA

Front 26

Name 5 proto-oncogenes and defects

Back 26

ras
src
sis
erb B
myc

Front 27

ras

Back 27

ras (G protein defect)

Front 28

src

Back 28

src (tyrosine kinase defect)

Front 29

sis

Back 29

sis (platelet derived growth factor receptor defect)

Front 30

erb B

Back 30

erb B (epidermal growht factor receptor defect)

Front 31

myc

Back 31

myc (transcription)

Front 32

Genetic defect in Li-Fraumeni syndrome and tumors

Back 32

p53
child sarcomas
bresat CA
brain tumors
leukemia
adrenal CA

Front 33

Genetic defects a/w medullary CA of thyroid

Back 33

MENIN
Ret proto-oncogene

Front 34

Genes a/w colon CA

Back 34

APC, p53, DCC, K-ras
does not go to bone

Front 35

#1 CA to mets to axillary

Back 35

lymphoma (breast, melanoma)

Front 36

#1 CA to mets to bone

Back 36

breast

Front 37

#1 CA to mets to SB

Back 37

melanoma

Front 38

ovarian mets

Back 38

stomach and colon

Front 39

supraclavicular nodes

Back 39

neck
breast
lung
stomach
pancreas

Front 40

4 phases of clinical trials

Back 40

safe?
effective?
better?
implementation and marketing

Front 41

5YSR of colon mets to liver

Back 41

25% if resected