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12 Cards in this Set

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  • Back
What is the half-life of articular cartilage?
117 years
Because cartilage has such a long half-life, what is the rate of cartilage synthesis in adulthood?
Markedly diminished relative to earlier in life
What is the basic mechanism by which normal cartilage ages?
Passive glycation
What is the net effect of this process?
Increased cartilage stiffness (modulus of elasticity)
With aging, what changes are seen in chondrocyte number?
Decreases
What changes are seen in chondrocyte size?
Increases
What changes are seen in collagen variability?
Increases
What changes are seen in total proteoglycan concentration?
Decreases
What is the corresponding change in water content?
Decreases
In normal aging, what happens to chondroitin 4 concentration as a
percentage of total chondroitin?
Decreases
What happens to keratan sulfate concentration?
Increases
Again, what is the net effect on modulus of elasticity?
Increased (increased cartilage stiffness)