Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
54 Cards in this Set
- Front
- Back
|
Neoplastic proliferation or accumulation of leukocyte with or without involvement of peripheral organ |
Leukemia |
|
|
Risk factor for leukemia |
FAM.history(gen.abnormalities-down syndrome Benzene exp Tobacco
|
|
|
Onset of acute leukemia |
1/2 of cases in children<14 years old |
|
|
Elevated proliferative predominance in immature cell type(blast) |
Acute leukemia |
|
|
Acute leukemia is fatal in |
3 months |
|
|
Divided principal lineage |
Acute myeloid leukemia Acute lymphocytic leukemia |
|
|
Who criteria for diagnosis |
Grequal 20%NCB |
|
|
Fab classification |
Grequal of NCB |
|
|
Leukemia laboratory diag |
J |
|
|
Leukemoid reaction |
M |
|
|
Most common type of leukemia |
AML |
|
|
Presence of Auer rods-fused lysosomal granules in cytoplasm |
AML |
|
|
Lack cytoplasmic granules |
Type 1 blast |
|
|
Small number primary |
Type II |
|
|
Most common. Type of leukemia in children |
ALL |
|
|
Positive for TDT |
ALL |
|
|
Blast are small and uneven in size |
L1 |
|
|
Blast are somewhat large and have various morpho |
L2 |
|
|
Blast generally large |
L3 |
|
|
More abundant azurophilic granules |
Type III |
|
|
Presence of cytoplasmic and nuclear vacuoles is char of this diagnosis |
ALL |
|
|
Minimally differentiated |
AML-MO |
|
|
Without maturation |
AML-M1 |
|
|
Grequal 30% of nucleated cell are |
T1-T11 blast |
|
|
<10% exhibiting beyond blast last stage |
AML-M1 |
|
|
Immunophenotype AML-M1 |
CD13,CD14,CD33,HLA-DD |
|
|
Chromosome abnormalities of AML-M1 |
Philadelphia chromosome 857 |
|
|
Staining of AML-M1 |
Grequal 3% myeloperoxidase and Sudan black B |
|
|
Auer rods infrequent |
AML-1 |
|
|
Most common type |
AML-2 |
|
|
<20%cells monocytic lineage |
Aml-2 |
|
|
Staining for AML-M2 |
Grequal 3% blast are positive Sudan black B ,myeloperoxidase |
|
|
Immunophenophenotype of AML-2 |
Tanan -CD11 |
|
|
Promyelocytic leukemia |
AML-3 |
|
|
Grequal 30% blast (t123) |
AML-3 |
|
|
Abnormal promyelocyte with numerous granules |
AML-M3 |
|
|
Auer rods are frequent |
AML-M3 |
|
|
Staining sa AML-M3 |
>85% are Sudan black b and myeloperoxidase |
|
|
Chromosome abnormality of AML-M3 |
T(15--17)unique to promyelocytic leukemia |
|
|
Ass.Dissiminated intravascular coagulation |
AML-M3 |
|
|
Myelomonocytic leukemia |
AML-M4 |
|
|
Grequal 30% leukemia nucleated cell t1t11 |
AML-M4 |
|
|
Staining Sudan black b,myeloperoxidase,nse |
AML-M4 |
|
|
Monocytic leukemia |
AML-M5 |
|
|
Staining for monocytic leukemia |
<20% leukemic cells Sudan black b ,myeloperoxidase (+) Grequal 80% a napthyl acetate esterase and a napthyl butyrate esterase |
|
|
Di Guglielmo syndrome/erythroleukemia |
AML-M6 |
|
|
Grequal 50% rbc |
AML-M6 |
|
|
>30% non erythroid cell are blast(T1-3 |
AML-M6 |
|
|
PAS positive |
AML-M6 |
|
|
Positive glycophorin A |
AML-M6 |
|
|
Megakarhocytic leukemia |
AML-M7 |
|
|
Grequal 30% has myeloblast and megakaryoblast |
AML-M7 |
|
|
Platelet peroxidase |
AML-M7 |
|
|
Glycophorin GP IB and GP IIB /IIIa |
AML-M7 |
