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31 Cards in this Set
- Front
- Back
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Autosomal dominant ,dominantly inherited defect of terminal neutrophil differentiation due to defect in nucleic acid metabolism |
Pelger huet anomaly |
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Morphology of pelger huet anomaly |
Nucleus fail to undergo segmentation,it fails to form more than 2 segments |
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Heterozygous form of pelger huet anomaly |
Hyposegmented,bilobed,spectacle -pence nez nuclei |
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Homozygous form of pelger huet anomaly |
Rare ,neutrophil contain single round eccentric nuclei with clumped chromati n and little segmentation |
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Function of pelger huet anomaly |
Normal neutrophilic function/natural resistance to infection |
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Benign autosomal dominant |
Hereditary hypersegmentation |
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Morphology |
Five or more nuclear lobes -single 6 lobes of 100 cell dif |
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Autosomal recessive trait multisystem disease |
CHA |
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Due to defective function ,chemotaxis |
Recurrent bacterial infection |
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Due to abnormal granules in melanocyte |
Oculocutaneous albinism |
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Due to platelet granule defect |
Mild bleeding disorders |
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Morphology CHA |
Large lysosomal cytoplasmic granules |
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Rare autosomal dominant abnormality -non muscle myosin heavy chain 9 (chromosome 22) |
May hegglin anomaly |
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Clinical for may hegglin |
Most patient are clinically asymptomatic |
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Dohle body like inclusion |
May hegglin anomaly |
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Thrombocytopenia with giant abnormal platelets |
May hegglin anomaly |
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Association of hunter and hurler syndrome |
Alder Reilly anomaly |
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Lack lysosomal enzyme to break mucopolysaccharide |
Alder Reilly anomaly |
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Dense azurophilic granules in leukocyte |
Alder Reilly |
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Metachromatic granules seen in leukocyte surrounded by clear zone seen in lymphocyte |
Alder reilly |
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Can be differentiated from inherited by presence of >10% of normal 3 lobed neutrophil |
Pseudo pelger huet anomaly |
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Seen in severe inflammatory states |
Toxic granulation |
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is thought to be due to impaired cytoplasm maturation in effort to rapidly generate large number |
Toxic granulation |
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Toxic granulation are azurophilic that are found in |
Promyelocyte,metamyelocyte,band,segment |
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Single multiple blue cytoplasmic inclusion |
Dohle bodies |
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Associated with myeloid left shift and seen in conjunction with toxic granulocyte |
Dohle bodies |
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Represent remnant's of rough endoplasmic reticulum |
Dohle bodies |
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Seen in burns surgery and infection |
Dohle bodies |
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Larger than may hegglin anomaly |
Dohle bodies |
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Implies that phagocytosis has occured |
Degranulation |
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May mean degeneration ,implies than phagocytosos |
Vacuolization |
