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28 Cards in this Set
- Front
- Back
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antibody
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a large Y-shaped protein that cells of the immune system, B lymphocytes, produce to fight invaders
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Monoclonal antibodies (mAbs)
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are made by a single B lymphocyte so they attack only one single target
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Murine (mouse) mAbs
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derived entirely from mice
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Effects of HAMA – Human anti-mouse antibody response
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joint swelling, rashes, and kidney failure
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Chimeric mAb
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A mAb constructed from a variable region derived from a mouse, and the constant region derived from a human source.
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Humanized mAb
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A mAb constructed with only antigen-binding regions derived from a mouse, and the remainder of the molecule derived from a human
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What is the half life of mAb?
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The half-life of a mAb in circulation is usually between 2 and 4 days.
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What are some of the uses of mAbs for drug targeting?
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Enhancing effector functions, direct arming, indirect arming, and pre-targeting.
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What is non-Hodgkin's lymphoma?
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A cancer of the B cells that most commonly occurs in the lymph nodes.
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What is Rituximab (Rituxin)?
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It is a therapeutic antibody that binds to the CD20 protein found on normal and cancerous B cells.
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What does Rituximab (Rituxin) do?
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After binding to the CD20 protein on B cells, it recruits other immune cells, such as phagocytes, to destroy the B cells. After the drug has left the body, normal B cells can begin to grow again.
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What can you use radioactive mAbs for?
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Imaging and destruction of infected cells.
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What is a tumor activated prodrug (TAP)?
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A TAP is a mAb that also has one or more anti-cancer drugs on it. It binds to and enters specific cells and releases its drugs only into the cell bound by the mAb.
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What is a benefit of using a tumor activated prodrug?
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A TAP can only release its anti-cancer drugs into the cells to which it binds so it leaves healthy cells untreated.
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antibody
|
a large Y-shaped protein that cells of the immune system, B lymphocytes, produce to fight invaders
|
|
|
Monoclonal antibodies (mAbs)
|
are made by a single B lymphocyte so they attack only one single target
|
|
|
Murine (mouse) mAbs
|
derived entirely from mice
|
|
|
Effects of HAMA – Human anti-mouse antibody response
|
joint swelling, rashes, and kidney failure
|
|
|
Chimeric mAb
|
A mAb constructed from a variable region derived from a mouse, and the constant region derived from a human source.
|
|
|
Humanized mAb
|
A mAb constructed with only antigen-binding regions derived from a mouse, and the remainder of the molecule derived from a human
|
|
|
What is the half life of mAb?
|
The half-life of a mAb in circulation is usually between 2 and 4 days.
|
|
|
What are some of the uses of mAbs for drug targeting?
|
Enhancing effector functions, direct arming, indirect arming, and pre-targeting.
|
|
|
What is non-Hodgkin's lymphoma?
|
A cancer of the B cells that most commonly occurs in the lymph nodes.
|
|
|
What is Rituximab (Rituxin)?
|
It is a therapeutic antibody that binds to the CD20 protein found on normal and cancerous B cells.
|
|
|
What does Rituximab (Rituxin) do?
|
After binding to the CD20 protein on B cells, it recruits other immune cells, such as phagocytes, to destroy the B cells. After the drug has left the body, normal B cells can begin to grow again.
|
|
|
What can you use radioactive mAbs for?
|
Imaging and destruction of infected cells.
|
|
|
What is a tumor activated prodrug (TAP)?
|
A TAP is a mAb that also has one or more anti-cancer drugs on it. It binds to and enters specific cells and releases its drugs only into the cell bound by the mAb.
|
|
|
What is a benefit of using a tumor activated prodrug?
|
A TAP can only release its anti-cancer drugs into the cells to which it binds so it leaves healthy cells untreated.
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