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24 Cards in this Set
- Front
- Back
What drug has this structure? What is its target and what nucleotide does it mimic?
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Azidothymidine (AZT), a.k.a. Zidovudine. It targets HIV reverse transcriptase by mimicking deoxythymidine.
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What drug has this structure? What does it target and what nucleotide does it mimic?
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Didanosine. It targets HIV reverse transcriptase by mimicking deoxyadenosine.
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What drug has this structure? What is its target and what nucleotide does it mimic?
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Abacavir. It targets HIV reverse transcriptase by mimicking deoxyguanosine.
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What drug has this structure? What is its target and what nucleotide does it mimic?
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Zalcitabine. It targets HIV reverse transcriptase by mimicking deoxycytidine.
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What is this structure and what is its significance?
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2',3'-Dideoxyadenosine Triphosphate. It is the active metabolite of Didanosine that targets HIV reverse transcriptase by mimicking the active deoxyadenosine triphosphate metabolite.
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What drug has this structure? What does it target and what nucleotide does it mimic?
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Tenofovir Disoproxil. It targets HIV reverse transcriptase by mimicking deoxyadenosine monophosphate.
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What drug has this structure? What is its target?
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Saquinavir. It inhibits both the HIV-1 and HIV-2 proteases.
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What drug has this structure? What is its target?
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Ritonavir. Originally developed as an inhibitor of HIV protease, it is now widely used as a booster of other protease inhibitors due to its inhibition of CYP3A4.
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What drug has this structure and what is its target?
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Lopinavir. It is an inhibitor of HIV protease. Lopinavir is used in combination with ritonavir, which functions as a CYP3A4 inhibitor. The combination is marketed under the trade name Kaletra.
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What drug has this structure and what is its target?
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Indinavir. It is an inhibitor of HIV protease.
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What drug has this structure and what is its target?
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Amprenavir. It is an inhibitor of HIV protease.
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What drug has this structure and what makes it unique among protease inhibitors? With what other protease inhibitor is it co-administered and why?
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Tipranavir. It is unique in that it is the first in a new class of non-peptidic HIV-1 protease inhibitors and is active against HIV-1 strains that are resistant to other protease inhibitors. It is co-administered with ritonavir, which inhibits CYP3A4 to optimize the Tipranavir's pharmacokinetic profile.
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What drug has this structure and what is its target?
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Maraviroc. It inhibits the cellular entry of HIV-1 by blocking the interaction between HIV-1 and the CCR5 co-receptor on host cells.
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What drug has this structure and what is its target?
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Raltegravir. It is an HIV integrase inhibitor, thus functioning to preclude the integration of viral genetic material into human chromosomes.
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What drug has this structure and what is its target?
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Memantine. It is an NMDA (N-methyl-D-aspartate) receptor antagonist used to treatment the symptoms of moderate-to-severe Alzheimer's Disease.
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What drug has this structure and what is its target?
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Tacrine. It is a cholinesterase inhibitor, the first approved for the treatment of Alzheimer's Disease.
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What drug has this structure and what is its target?
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Alendronate. It inhibits osteoclast bone resorption by mimicing the endogenous regulator of bone turnover, pyrophosphate.
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What drug has this structure and what is its target?
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Odanacatib. It inhibits cathepsin K, the major active enzyme in osterclasts, which are the bone cells responsible for bone resorption.
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What drug has this structure and what is its target?
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Bortezomib. It targets the 26S proteasome for the treatment of cancer (multiple myeloma).
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What drug has this structure and what is its target?
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Aliskiren. This antihypertensive was the first orally active renin inhibitor.
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What drug has this structure and what is its target?
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Captopril. It inhibits angiotensin-converting enzyme (ACE) , which is responsible for cleaving angiotensin I to produce antiotension II. Fun Fact: Captopril became the first ACE inhibitor on the market for the treatment of hypertension.
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What drug has this structure and what is its target?
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Enalapril. The active metabolite of this prodrug inhibits angiotensin-converting enzyme (ACE) , which is responsible for cleaving angiotensin I to produce antiotension II.
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What drug has this structure and what is its target?
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Fosinopril. The active metabolite of this phosphinate-containing prodrug inhibits angiotensin-converting enzyme (ACE) , which is responsible for cleaving angiotensin I to produce antiotension II.
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What drug has this structure and what is its target?
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Carfilzomib. Target is proteasome 26S.
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