Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
|
Helicobacter pylori
(infection induces gastric epithelial cell proliferation) |
small curved bacillus
gram negative microaerophilic LARGE amounts of urease |
|
|
HP disease
|
acute upper gastrointestinal illness
*nausea, upper abdominal pain, burping chronic gastritis (all strains) *usually asymptomatic *non-ulcar dyspepsia (pain) Duodenal, gastric ulcer (some strains) gastric carcinoma, gastric lymphoma |
|
|
HP pathogenesis
|
adherence to gastric mucosal epithelial cells
non-opsonic binding to neutrophils production of urease *ammonia increases local PH and is toxic to cells 1. vacuolating cytotoxin *inserts ion channel in epithelial cell membrane and secreation of urea into gastric lumen *damange to mito *immunosuppressive to T cells 2. CagA *protein secreted into target by type IV system *actin skeleton rearrangement |
|
|
HP DX
|
non invasive
1. serology 2. C14 or C13 urea breath test 3. fecal antigen test invasive 1. urease test of biopsy material 2. culture and histology of biopsy material |
|
|
HP TX
|
proton pump inhibitor + 2 AB
fecal-oral, oral-oral transmission |
