Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Which biological effects can a drug have when it binds to a receptor?
|
Agonistic, antagonistic, inverse agonistic effect, or positive or negative allosteric modulating effect. |
|
|
Name some drugs which bind to allosteric sites on receptors. |
Benzodiazepines, barbiturates bind to allosteric sites on the GABA-A receptor. |
|
|
Name some drugs which block ion channels. |
Local anaesthetics like lidocaine block voltage-gated sodium channels. |
|
|
Name some drugs which are allosteric modulators of ion channels. |
Dihydropyridines like nifedipine are negative modulators for voltage-gated calcium channels. |
|
|
In what ways can a drug alter the effect of an enzyme? |
Drugs can competitively or non-competitively inhibit enzymes. |
|
|
Name some drugs which irreversibly inhibit enzymes. |
Aspirin (COX), organophosphates (acetylcholinesterase). |
|
|
Name some drugs which increase enzyme activity indirectly.
|
Organic nitrates, which indirectly stimulate guanylyl cyclase. |
|
|
Name some drugs which bind to DNA. |
Certain anticancer drugs bind to and alkylate DNA. |
|
|
Name some drugs which don't bind to proteins or DNA. |
Antacids, osmotic laxatives, osmotic diuretics, sugammadex. |
