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15 Cards in this Set
- Front
- Back
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pro emesis drugs
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IPecac syrup
apomorphine |
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ipecac syrup mOA
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stimulate chemo trigger zone
irriatate gastric mucosa |
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ipecac syrup SE
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must vomit cardiotoxic
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apomorphine mOA & SE
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Stimulates Chemo trigger zone
respiratory depression |
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ANti emetics possible MoA
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Anti DOpa
AntiCholinergic antihistamine anti-serotonin substance p/neurokinin-1-r antagonist cannabid agonist |
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prochlorperazine
uses moa |
ANTI EMETIC DUE TO :
Anti-Dopa (emesis) anti-cholinerg (motion) some anti-histamine(?) two other AZINES also (P.C.P) |
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Metaclorpramine Moa
uses |
antiemetic and
improved gastric emptying peripheral cholinergic stimulant (main function increased G-motility) peripher. DOPAmine antag. (increased gastric contract SI transit) Central D-R antag ( anti-emetic) |
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Scopalamine uses moa SE
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anticholinergic-central
motion sickness patch------mydiriasis dry as a bone red beet, mad hatter |
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Antihistamines as antiemetics
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cyclizine hydroxyzine diphenhydramine (benadryl)
1st generation (central acting H1) |
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ant serotonins as
anti-emetics |
ondansetron granisetron
5ht-3 antagonists |
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chemo emesis
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multidrug but setrons (anti 5ht-3)
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Cannabid R agonists
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dronabinol nabilone
NABI |
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Aprepitant mOA, Uses, SE
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Substance P, Neurokinin-1 R
Antagonist Anti emesis in chemo usually in combo SE-hiccups, inhibits cyp3a4 long term fatique add steroids to most |
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metocloparamide SEs
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(antemesis-pro motility)
stimulates prolactin secretion(D2)----Menstrual probs galactorrhea motor probs insomnia and fatigue also |
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cholinergic antimotion
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scopolamine
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