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14 Cards in this Set

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  • Back
Age-Related Change for:
Myocytes
Dec number, inc size; inc fibrocytes
Age-Related Change for:
LV Stiffness
Inc (dec compliance)
Age-Related Change for:
LV Wall Thickness
Inc
Age-Related Change for:
Systemic Vascular Resistance
Inc
Age-Related Change for:
Left Atrium
Inc
Age-Related Change for:
LV Diastolic Passive Filling
Dec (atrial contraction more important)
Age-Related Change for:
Maximum Heart Rate
Dec
Age-Related Change for:
Maximum Cardiac Output
Dec
Age-Related Change for:
Max Volume of Oxygen
Dec
Age-Related Change for:
Vasodilation with exercise
Dec
Diastolic Changes with Age
Failure of LV relaxation reduces passive filling, thus more filling generated by atrial contraction

Accordingly, rapid heart rates that shorten diastole compromise cardiac output

Interference with atrial contraction (AFib) further reduces diastolic filling

Active filling also impaired (Ca2+ handling)
Blood Pressure Changes with Age
Systolic pressure much more accountable than diastolic pressure for things like stroke and coronary heart dz

Widening Pulse Pressure increases with age (not just systolic) is primary villain in producing disease states associated with elevated BP
Arterial Changes with Aging
Inc'd vascular stiffness
Inc pulsatile load (inc systolic and pulse pressures)
What aging-related changes increase risk for cardiovascular diseases?
Dec CV reserve, LV stiffness-->CHF (PEF)

Dec baro-reflex sensitivity, autonomic dysfn-->syncope

BP and PP changes-->HTN, stroke

Sinue node atrophy, dysfn-->AF

Inc FIBRINOGEN, Factors V, VIII, IX-->Thrombosis

Valvular Sclerosis, Ca2+-->Murmurs, stenosis

Atherosclerosis-->Inc ischemia, AMI