Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
|
1. Define micromeritics.
|
a. Micromeritics – the science and technology of small particles.
i. Particle size affects physical stability and therapeutic response of: 1. Suspensions 2. Emulsions 3. Tablets 4. Capsules |
|
|
2. Describe the influence of particle size reduction on a dosage form. (describe comminution and the effects of particle size)
|
a. Comminution – mechanical process of reducing a solid to a smaller state of subdivision.
b. Particle size influences: i. Appearance ii. Texture iii. Taste of drug iv. Rate of absorption by patient |
|
|
3. Briefly describe the various methods used to determine/measure a particle size.
|
a. Sieving: establish dist particle size in powder form, from large holes (top) to progress smaller holes (bottom).
b. Laser Diffraction: shine laser beam on loose particle. Scattered light has pattern unique for size of given material. c. Scanning Electron Microscope (SEM): probes surface of particle that is covered in a thin layer of gold and bombarded by electrons. d. Transmission Electron Microscope (TEM): probe internal structure of particle. |
|
|
5. Briefly explain particle size distribution & importance of surface area.
|
a. Particle shape affects flow in manufacturing and potentially affect surface area
b. Surface area is important in dissolution rate c. Absorption Method – determines surface area. |
|
|
6. Discuss powder characterization & angle of repose. What is the AOR and what is it determined by?
|
a. When bulk granular materials are poured onto a horizontal surface, a conical pile will form.
b. The Angle of Repose - The internal angle b/w the surface of the pile and the horizontal surface. c. Angle of Repose determined by: i. Friction ii. Cohesion iii. Shapes of the particles |
