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17 Cards in this Set
- Front
- Back
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What 2 types of allergy are involved in Type 1 Hypersensitivity reaction?
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Anaphylactic and Atopic
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What is the time frame for a Type 1 reaction?
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Very rapid
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What 2 things cross-link to IgE in a Type 1 Hypersensitivity reaction?
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Mast Cells and Basophils
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What happens to vessels in a Type 1 HS reaction?
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Increase in vascular permeability
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What happens in a Type 2 HS reaction?
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IgM and IgG bind to an "enemy" cell, which is actually a self cell
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What is the target of the antibodies in a Type 2 HS reaction?
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Antibodies against self
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Which complex defines a Type 3 HS reaction?
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Antigen-Antibody Complexes
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What does the Antibody-Antigen complex attach to?
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Complement
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What is serum sickness?
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Immune complex where AB's to foreign proteins are produces
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What do immune complexes do in a Type 3 HS reaction?
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Deposit in membranes and fix complement
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What is the time frame for a Type 3 HS reaction?
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5-12 hrs
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What is the Arthus Reaction in a Type 3 HS reaction?
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Intradermal injection causes the AA-Complexes to form in the skin
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What are the symptoms of the Arthus Reaction?
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Edema, Necrosis and activation of complement at the injection site
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What is the time frame for a Type 4 HS reaction?
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24-48 Hrs
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What is the most classic example of a Type 4 HS reaction?
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TB skin Test
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What happens at the site of contact in a Type 4 HS reaction?
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T-cell mediated macrophage activation
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What is the mnemonic for the HS reactions?
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ACID
A - Anaphylactic and Atopic (Type 1) C - Cytotoxic (Type 2) I - Immune Complex (Type 3) D - Delayed, Cell Mediated (Type 4) |
