2 Immuno: Adaptive Immunity

Front 1

gen

Back 1

gen:
- immune response: Ag captured, processed, and presented by APCs
- must be done so B and T cells recognize

Front 2

antigen

Back 2

antigen drives the adaptive immune response by stimulatig B and T cells

Front 3

APCs

Back 3

APCs:
- Ag needs to be acquired and presented to T cells by APCs

Front 4

MHC II

Back 4

1. APCs present exogenous Ag to Th cells by processing, loading and presenting Ag to an MHC II
2. APCs shuttle MHC-II-Ag complex to its surface for presentation
3. Th cells can only see Ag if its presented on the surface of an APC within the context of self MHC II
* only APCs can take up, process and present exogenous Ag via MHC II

Front 5

MHC I

Back 5

almost any nucleated cell that is infected by intracellular pathogens can process and present endogenous Ag to CTLs ( cytotoxic T cells) via MHC I

Front 6

BCR

Back 6

B cells have a BCR on the surface that can recognize/ interact with soluble, free in solution

Front 7

TCR

Back 7

T cells have a TCR on the surface that can recognize Ag only when presented by an APC or an infected, nucleated cell within the context of self MHC

Front 8

Th cells

Back 8

B cells need help (cell to cell interactions and cytokines) from Th cells to make Ab
- B cells make Ab specific for the Ag that the B cell recognized initially

Front 9

MHC II

Back 9

1. APCs proccess and loading Ag onto an MHC II molecule
2. APCs shuttle MHC II- Ag complex to its surface for presentation to Th cells
3. Th cells can only see Ag if presented on the surface of an APC in context of self MHC II

Front 10

MHC I

Back 10

almost any nucleated cell infected by intracellular pathogens can process and present endogenous Ag to CTLs via self MHC I

Front 11

BCR

Back 11

BCR: cell surface receptors of B lymphocytes
- recognizes/ interacts with soluble, free in solution Ag

Front 12

TCR

Back 12

TCR:
- surface receptors of T cells
- recognize Ag only when presented by:
1. an APC -or-
2. an infected, nucleated cell
- within the context of self MHC

Front 13

Th cells

Back 13

- B cells need cell to cell interactions and cytokines from Th cells to make Ab
- B cells make Ab specific for the Ag initially recognized