11 Meds: Antidepressants-Maois

Front 1

3 examples of MAOIs?

Back 1

1. Phenelzine sulfate (Nardil)
2. isocarboxazid (Marplan)
3. tranylcpromide (Parnate)

Front 2

moa of MAOIs?

Back 2

interfere w/ monoamine oxidase, which allows for increased conc. of NTs (E, NE, S) in synaptic space, causing stabilization of mood

Front 3

2 indications for MAOIs?

Back 3

1. depression
2. chronic pain syndromes

Front 4

When might hypertensive crisis occur?

Back 4

MAOI + tyramine-containing foods

MAOI + OTC meds containing ephedrine, pseudoephedrine

Front 5

List of foods containing tyramine? (15)

Back 5

1. aged cheese
2. bologna
3. pepperoni
4. salami
5. figs
6. bananas
7. raisins
8. beer
9. chianti red wine
10. liver
11. yogurt
12. herring
13. yeast
14. sour cream
15. pickled products

Front 6

4 potential side effects of MAOIs?

Back 6

1. photosensitivity
2. weight gain
3. sexual dysfunction
4. orthostatic hypotension

Front 7

Are MAOIs the first-line drugs for depression?

Back 7

no

Front 8

Which drugs canNOT be combined w/ MAOIs? (4)

Back 8

1. SSRIs
2. antihypertensive meds (caution)
3. CNS depressants
4. alcohol

Front 9

When should a pt d/c the MAOI prior to general anesthesia?

Back 9

d/c MAOIs 10 days prior to general anesthesia

Front 10

What do MAOIs do to one's seizure threshold?

Back 10

they LOWER the seizure threshold

Front 11

Which GU side effect should you monitor for in a pt taking an MAOI?

Back 11

urinary retention

Front 12

Which drugs should be avoided while a pt is taking an MAOI? (3)

Back 12

1. caffeine
2. amphetamines
3. antihistamines

Front 13

How long does it take for an MAOI to work?

Back 13

3-4 wk

Front 14

When can a pt who has finished taking MAOIs start taking a TCA?

Back 14

can take a TCA until 3 wk stopping MAOI inhibitors

Front 15

What are the signs of a hypertensive crisis? (5)

Back 15

1. headache
2. sweating
3. palpitations
4. stiff neck
5. intracranial hemorrhage