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13 Cards in this Set
- Front
- Back
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What are the indications for fibrinolytics? |
- Early STEMI - Early ischaemic stroke - Massive pulmonary embolism Fibrinolytics or thrombolytics are drugs that lyse thrombi that have already been formed. PCI is preferred instead of fibrinolytics, if available. |
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Name natural fibrinolytics |
Streptokinase, urokinase |
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Side effect of streptokinase? |
It can activate plasminogen even if its not bound to fibrin and cause bleedings. |
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Name recombinant fibrinolytics |
Alteplase, duteplase, tenecteplase |
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Mechanism of action of recombinant fibrinolytics? |
Recombinant fibrinolytics are tissue plasminogen activator-analogues, so they convert plasminogen into plasmin, which will cleave fibrin. |
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When are antifibrinolytics indicated? |
To stop severe bleeding like during menorrhagia, tooth extraction, during surgery or as antidote to fibrinolytics. |
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Mechanism of action of antifibrinolytics? |
Inhibit conversion of plasminogen into plasmin |
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Name antifibrinolytic drugs |
Tranexamic acid and Aprotinin |
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Mechanism of action of hemostatic drugs? |
They stop bleeding by other mechanisms than inhibiting fibrinolysis by applying them directly to the external bleeding. |
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Sponge made of gelatine which induces hemostasis? |
Spongostan |
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What are styptics? |
Hemostatic agents that work by contracting tissue to seal damaged blood vessels. Agents that cause vessel contractions are called astrigents. |
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What can be used as an astrigent? |
Adrenaline. |
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Name some haemostatic drugs |
- Spongostan - Thrombin powder - Styptics - Ethamsylate |
