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62 Cards in this Set
- Front
- Back
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Rotavirus:
-Symptoms: __1__ -More severe in __2__ |
1. Watery Diarrhea with no Blood or Leukocytes
- Fever - Vomiting 2. young children |
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Pathology of Rotavirus:
-mostly affects the __1__ -replicate in __2__ -excreted in __3__ -detected by __4__ |
1. Small Intestine
2. epithelial cells 3. stool 4. EM or Enzyme immunoassay to detect antigen |
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EM appearance of Rotavirus
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Spoked-wheel
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Describe the symptoms with Calici/Norwalk virus (3)
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1. Watery Diarrhea
2. Abdominal cramps 3. Vomiting *24-72 hours |
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About what percent exposed to Calicivirus will have symptoms?
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50%
But all individuals secrete the virus and spread it |
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Diagnosis of Calicivirus/Norwalk
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CLINICAL
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Histology of Calicivirus
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SMALL
Star-like appearance |
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Associated with Infantile Diarrhea and cannot be isolated in the laboratory
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Adenovirus 40 and 41
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Adenovirus 40/41:
-Symptoms -Incubation and length of illness |
- Mild Diarrhea - Profound Dehydration
Incubation: 3-10 days Length: 6-9 DAYS!!! |
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Diagnosis of Adenovirus 40/41
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CLINICAL
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Incubation period for Measles
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10 days
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Symptoms of Measles
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3 C's: Cough, Coryza, Conjunctivitis followed by RASH on 4th day!!!
Koplik spots |
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Cells that are distinctive to Measles
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Warthin-Finkeldey MNGC's in pneumonia
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Explain the RASH in Measles
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-Appears on 3rd-4th day
-Red papules that COALESCE -first starts on Forehead, hairline and then spreads down the body -includes PALMS AND SOLES |
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4 Complications of Measles
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1. Giant Cell Pneumonia
2. Otitis Media 3. POSTINFECTIOUS ENCEPHALITIS 4. SUBACUTE SCLEROSING PANENCEPHALITIS (4-17 years later) |
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When was Measles vaccine introduced?
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1968 and has drastically reduced # of cases
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Rubella Incubation period
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10-21 days
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Symptoms of Rubella infection
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1. Low fever
2. Lymphadenopathy 3. Maculopapular Rash |
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Where can Rubella disemminate to?
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All organs
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Diagnosis of Rubella
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Serology (IgM)
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Congenital Rubella Syndrome:
-During which Trimerster: 1 -Clinical Triad: 2 |
1. 1st
2. Deafness, Cataracts, Heart Disease, Glaucoma, Mental Retardation |
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Clinical Symptoms of Mumps
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"MOP"
Meningitis Orchitis PAROTITIS |
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Diagnosis of Mumps
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Serology
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Parvovirus B19 causes:
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Erythema Infectiosum = "slapped cheeck"
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Parvo B19 infects these cells
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Erythroid Precursors that leads to transient anemia
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High risk groups for high morbidity with Parvo B19 infection
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Sickle cell patients
Thalessemia Immunodeficient Pregnant (Hydrops fetalis) |
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When was Endemic Smallpox eradicated?
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1979
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Molluscum Contagiosum is caused by this virus
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Poxvirus
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Appearance of Molluscum Contagiosum
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Wart-like lesion with a dimpled center
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What virus is this?
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Molluscum contagiousum
Poxvirus |
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Pathology of HPV infected cells is a characteristic CPE termed ________
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Koilocytosis
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What is Condylomata Acuminata?
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HPV warts on genitals
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What are Koilocytes?
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vacuolated epidermal cells with shrunken hyperchromatic nuclei
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Herpesviruses cause severe disease in these two groups
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Neonates
Immunocompromised |
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Cowdry Type A (acidophilic) Nuclear Inclusions
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Herpesvirus inclusion bodies
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HSV are shed from vesicles within the how many hours after onset of symptoms?
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24-48
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Smear used for Herpes and what will it show?
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Tzank
MNGC's |
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Describe Primary infection by HSV
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-Ulcerative lesions of gums, tongue, palate, tonsils
- Fever, Cervical Lymphadenopathy |
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Decscribe Recurrent Infections with HSV
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-preceded by burning, itching
-Erythema -> vesicles -> ulcers -> crust |
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VZV is a __1__ infection with the virus residing in the __2__
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1. lifelong
2. sensory ganglia |
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Reactivation of VZV =
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Zoster (Shingles)
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Incubation of VZV
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10-20 days
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Clincial manifestations of Varicella
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Fever, chills -> Vesicular lesions
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Complications of Varicella
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Bacterial Superinfection
Meningoencephalitis Pneumonia Hepatitis |
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Scratching the lesions
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What causes Secondary Bacteria infection in Varicella
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Histology of Vesicle sample from Varicella
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MNGC's
Cowdry Type A nuclear inclusions |
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Explain Shingles clinical features
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UNILATERAL vesicular rash
Excruciating pain |
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CMV is shed in ....
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pretty much all fluids
-urine, saliva, semen, breast milk |
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CMV is found in these cells
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Lymphocytes and Monocytes as a latent infection
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Clinical infections of CMV
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Mononucleosis (Monospot -)
Hepatitis |
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DOC for CMV
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gancyclovir
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Histology of CMV
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Owl's eye nuclear inclusion
Swollen cells (cytomegalic) |
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EBV:
-age who is usually asymptomatic -Age who develop Mononucleosis |
- children
-Older children and adults |
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Diagnosis of EBV (2)
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1. Heterophil Ab's (Monospot)
2. EBV specific Antibody |
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EBV is associated with this disorder that must be differentiated from ACUTE REJECTION
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Posttransplant Lymphoproliferative Disorder (PTLD)
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Histology of PTLD
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**caused by EBV**
Lymphocytes -large and atypical -prominent nuclei -mitosis -INDIVIDUAL cell NECROSIS |
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EBV is also associated with these diseases
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African Burkitt's Lymphoma
Nasopharyngeal Carcinoma Hair Leucoplakia in IC'ed Interstitial Pneumonitis and Hepatitis in PEDIATRIC AIDS PATIENTS |
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HHV-6 causes this disease
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Roseola infantum (6th disease)
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Clinical features of Roseola infantum
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1. high fever (104 C)
2. neck lymphadenopathy 3. rash after 4 days |
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HHV-8 is associated with:
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Kaposi's Sarcoma
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Explain histology of Kaposi's sarcoma
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1. small slit-like vascular channels
2. extravasation of RBC's 3. spindle cells |
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Koplik spots
Measles |
What are these called?
What causes them? |
