The Physiological Effects of Caffeine Essay examples
What happen to the caffeine …show more content…
In early studies, caffeine was thought to inhibit phosphodiesterase, an enzyme which is responsible for degrading cAMP. This inhibition leads to an increase of cAMP, which is known to have the effects on excitatory neurotransmitters such as norepinephrine and dopamine. Therefore, caffeine would lead to higher activity of the excitatory neurotransmitter causing the stimulatory effects psychomotor (Glass et al. 1996). However, substantial inhibition of phosphodiesterases requires millimolar concentrations of caffeine, roughly 100 times the caffeine levels in the brain after ingestion of typical doses in man. Furthermore, some inhibitors of phosphodiesterase are 100-1000 times more potent than caffeine lack behavior effects.
The most important neurobiological effects of caffeine is its activity as an antagonist of the adenosine receptor. Recently, a variety of evidence has accumulated suggesting strongly that adenosine may mediate the behavioral influences of caffeine. Adenosine is an intermediary in a wide range of metabolic