I. INTRODUCTION
Summary.
T cells are one of the several types of lymphocytes that performs several functions in immunity. An example function is immune surveillance, a process in which foreign and diseased host cells are recognized and destroyed by natural killer cells. T cells function in immune surveillance by generating a T-cell response (TCR) which allow them to function in fighting against infection (Swann, J. B. et al, 2007). Recent findings indicate TCR and local non-related factors of the tissues result in the programming of tissue resident memory cells, a newly discovered group of lymphocytes. Hence, the main focus of the paper reviewed was on how T-cell antigen-dependent pathways effect the generation of skin-resident memory cells, formed from a polyclonal repertoire of cells that are stimulated by infection with an antigenically complex virus (MVA) and recombinant vaccine vector. The result generated indicated that at the site of an infection, …show more content…
In this paper I will summarize what is known about the Tissue resident memory T-cells and compare it with the experiment conducted in the reviewed paper with the goal of providing a clear understanding of one of the known functions of Tissue resident memory …show more content…
They are found mainly within epithelial barriers of non-lymphoid tissues such as skin surfaces and play a role in the accelerated protection of the body from reinfection. Tissue resident memory cells share a common core transcriptional program with their counterpart cells. This transcriptional program distinguishes them from other cells; tissue central memory cells (Tcm) and effector memory T-cell (Tem). Because little is known about Tissues resident memory T cells, various research has been conducted to analyze its function and significance in immune
Summary.
T cells are one of the several types of lymphocytes that performs several functions in immunity. An example function is immune surveillance, a process in which foreign and diseased host cells are recognized and destroyed by natural killer cells. T cells function in immune surveillance by generating a T-cell response (TCR) which allow them to function in fighting against infection (Swann, J. B. et al, 2007). Recent findings indicate TCR and local non-related factors of the tissues result in the programming of tissue resident memory cells, a newly discovered group of lymphocytes. Hence, the main focus of the paper reviewed was on how T-cell antigen-dependent pathways effect the generation of skin-resident memory cells, formed from a polyclonal repertoire of cells that are stimulated by infection with an antigenically complex virus (MVA) and recombinant vaccine vector. The result generated indicated that at the site of an infection, …show more content…
In this paper I will summarize what is known about the Tissue resident memory T-cells and compare it with the experiment conducted in the reviewed paper with the goal of providing a clear understanding of one of the known functions of Tissue resident memory …show more content…
They are found mainly within epithelial barriers of non-lymphoid tissues such as skin surfaces and play a role in the accelerated protection of the body from reinfection. Tissue resident memory cells share a common core transcriptional program with their counterpart cells. This transcriptional program distinguishes them from other cells; tissue central memory cells (Tcm) and effector memory T-cell (Tem). Because little is known about Tissues resident memory T cells, various research has been conducted to analyze its function and significance in immune