HDL Coder Implementation for Luo Rudy Phase 1 Excitation Modeling

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This paper presents the study of non-linear dynamic of cardiac excitation based on Luo Rudy Phase I (LR-I) model towards numerical solutions of ordinary differential equations (ODEs) responsible for cardiac excitation on FPGA. As computational modeling needs vast of simulation time, a real-time hardware implementation using FPGA could be the solution as it provides high configurability and performance. For rapid prototyping, the MATLAB Simulink offers a link with the FPGA which is an HDL Coder that capable to convert the MATLAB Simulink blocks into Very High Description Language (VHDL) and through an FPGA-in-the-loop, simulation for FPGA implementation can be done. Here, MATLAB Simulink successfully simulates the LR-I of excitation model …show more content…
As the time flies the models become more advance and very complex since number of variables parameters increased in order to represent the cellular process in more detail. Thus, the simulations also cause a new problem which is need more amount of computations in order to obtain the good results from the simulation [1]. Next, the hardware-implementation is the best solution to overcome the problems when dealing with the simulations method. The hardware implementation of the cardiac mathematical model that has been developed is hybrid hardware of analog and digital by using electronic circuits and dsPIC30f4011 microcontroller. This hybrid model encounter with some problems which are have to deal with the noise, limited input and output voltage range and gain. In addition, the hardware has been designed also big in size and high power consumption [1].
Therefore, the aim of this study to develop hardware-implemented cell models for Luo-Rudy phase I (LR-I) model. This model is described by a set of nonlinear Ordinary Differential Equations (ODEs) that includes eight (8) dynamic state variables for describing six (6) types of ion channel currents [9] will be developed in order to simulate action potentials in a variety of conditions, where the action potential provides a basis of the electrophysiological

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