COPD Case Study

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INTRODUCTION The modern view of COPD suggests that this - a progressive disease characterized by an inflammatory component, bronchial obstruction and structural changes in the lung tissue. And a significant role in the pathogenesis plays a variation of the immune reactivity. It is known that activation of immune reactions in COPD mediated effects on molecular cell systems a wide range of mediators, primarily cytokines that regulate the immune reactivity of the organism. [1] Established that are the main producers of cytokines and T-lymphocytes are activated monocytes / macrophages [2, 3]. Secreted they actively act as mediators in the inflammation, as a result of performing a number of protective functions [4,5]. In this connection, it is necessary to study the levels of cytokines that influence the development and course of chronic inflammation in the body [6].

Cytokines are physiological intracellular signaling proteins that many cells in the body are formed. Interleukin-6 act an essentially pro-inflammatory cytokine and has been involved to show an aspect in the systemic inflammation in patients along chronic obstructive lung disease COPD [7].however Human IL-8 is a compelling Chemoattractant and stimulant like Eosinophilic cells, As the main representative of the CXC Chemokines, is on the in vivo and vitro
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Favorable results drug, on the other hand actual limited by the small track (six weeks in each branch with 2 extra washes) and the very limited number of patients 42 in total [16]. Similar year In a wide, Multicentric trial Study in Primary Care, double-blind RCT 3 year track, trying to assess the number of exacerbations and Spirometric parameters in 3 branches Fluticasone Propionate, Acetylcysteine and placebo, with 286 patients. I do not found beneficial effect in all of the treatments

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