Alzheimer's Disease and Aluminium Essay

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Aluminium is present in the earth's crust in huge amount, mainly in the form of insoluble aluminium silicates. It is scarce in the human body which contain only 30-50 mg of that metal. This is due to the insolubility of aluminium, the presence of a barrier in the gastro-intestinal tract to soluble forms of aluminium, and the ability of the kidneys to excrete aluminium effectively in healthy people.
Aluminium is present in food occurs in additives, tea which is rich in aluminium, and drinking water which is treated with aluminium to remove organic residues. Aluminium is also present in large amounts in medications such as antacids or compound aspirin products.

Most of the aluminium in plasma is bound to the iron-transporting protein
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Injecting laboratory animals like rabbits with aluminium salts results in appearance of extensive neurofibrillary changes in the spinal cord and various cortical regions. Similar changes are evident in cats treated in this way, which show cognitive deficits. The proposal that Aluminium is responsible for brain changes in Alzheimer disease gained support from studies that have shown increased level of Aluminium in the neocortex of patients with Alzheimer disease in levels similar to that causing brain pathology in laboratory animals. Another support to the Aluminium hypothesis came from dementia seen in patients who undergo dialysis due to renal failure.
However, there are basic difficulties in explaining the available information from research studies on the role of Aluminium in development of Alzheimer disease. The neurofibrillary changes seen in animals treated with Aluminium is different from the characteristic of tangles of Alzheimer disease formed mainly of double helix filaments of the microtubule-associated tau protein. In addition, the neurofibrillary tangles are not found extensively in the spinal cord in Alzheimer disease. Animals exposed to Aluminium treatment do not develop neuritic plaques of the beta-amyloid.
In the progressive dementia that develops in prolonged dialysis there are focal neurological signs not

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