Zinc and Immunity
Various aspects of immune system are affected due to zinc (6,7,8). For normal development and function of cell mediated innate immunity, neutrophils and natural killer cells, zinc is essential element. The deficiency also affects the macrophages. The deficiency also affects adversely the growth and function of T and B cells. Besides zinc is an essential element needed for the synthesis of DNA, transcription of RNA, and activation of cells. Cytokines are adversely affected in terms of their secretion and function due to deficiency of zinc. Zinc deficiency also intensifies the apoptosis. It is also acting as an antioxidant and helps in the membrane stabilization. Deficiency of zinc leads to the atrophy of thymus and lymphoid …show more content…
T-cell activation or alteration of lymphokine production is induced by zic, which activates macrophages to promote bacterial clearance [34].
Zinc deficiency is characterized I the reduction of IL-2 and IFN- and both of the IL-2 and IFN- are generated by zinc supplements [13,34].
Zinc supplements have also found profound effect on the treatment of autoimmune disease. One study reported that the patients with rheumatoid arthritis were found to get beneficial effects from the symptoms of joint swelling, morning stiffness and walking by using zinc supplements
Various aspects of immune system are affected due to zinc (6,7,8). For normal development and function of cell mediated innate immunity, neutrophils and natural killer cells, zinc is essential element. The deficiency also affects the macrophages. The deficiency also affects adversely the growth and function of T and B cells. Besides zinc is an essential element needed for the synthesis of DNA, transcription of RNA, and activation of cells. Cytokines are adversely affected in terms of their secretion and function due to deficiency of zinc. Zinc deficiency also intensifies the apoptosis. It is also acting as an antioxidant and helps in the membrane stabilization. Deficiency of zinc leads to the atrophy of thymus and lymphoid …show more content…
T-cell activation or alteration of lymphokine production is induced by zic, which activates macrophages to promote bacterial clearance [34].
Zinc deficiency is characterized I the reduction of IL-2 and IFN- and both of the IL-2 and IFN- are generated by zinc supplements [13,34].
Zinc supplements have also found profound effect on the treatment of autoimmune disease. One study reported that the patients with rheumatoid arthritis were found to get beneficial effects from the symptoms of joint swelling, morning stiffness and walking by using zinc supplements