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What Is Polyoxyethylated Castors?

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Molecules like cyclosporine that are non-ionisable, lipophilic and non-polar are challenging to formulate due to their low solubility and no effect of pH on solubility, and they are also solubilised in non-aqueous solutions composed entirely of organic solvents. The combination of polyoxyethylated castor oil and ethanol that are water miscible surfactants and solvents can be used to solubilise the non-polar active ingredient, cyclosporine. Therefore, the excipients are appropriate for the formulation.
Polyoxyethylated castor oil is a surface active agent that increases the solubility of drugs that are poorly soluble in water with the formation of micelles. Surfactants have an amphipathic nature, so it will form micelles when placed in water,

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