Blood-Brain Barrier
The blood–brain barrier (BBB) is a highly specific permeable barrier that separates the blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The BBB is composed by brain endothelial cells, which is connected by tight junctions with high electrical resistivity . The BBB allows passage of water, gases and lipid soluble molecules by passive diffusion and selective transport of molecules such as glucose and amino acids . The blood–brain barrier prevents the entry of lipophilic, potential toxins in nervous system, by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are needed to form blood–brain barrier. A small region in the brain, including the circumventricular organs
The blood–brain barrier (BBB) is a highly specific permeable barrier that separates the blood from the brain extracellular fluid (BECF) in the central nervous system (CNS). The BBB is composed by brain endothelial cells, which is connected by tight junctions with high electrical resistivity . The BBB allows passage of water, gases and lipid soluble molecules by passive diffusion and selective transport of molecules such as glucose and amino acids . The blood–brain barrier prevents the entry of lipophilic, potential toxins in nervous system, by way of an active transport mechanism mediated by P-glycoprotein. Astrocytes are needed to form blood–brain barrier. A small region in the brain, including the circumventricular organs