Analysis Of Big Brother By Lionel Shriver

Lionel Shriver wrote in his book, Big Brother “However gnawing a deficiency, satiety is worse... We are meant to be hungry.” Sadly, for those people looking to lose weight, his statement is absolutely correct. Even though people are obese because they eat and don’t work out the calories they consume, it cannot be put in the same words for all. Every human body is different, every human mind percepts information in a different way and every human gene varies from person to person. Obesity is one mechanism that is different in every human and therefore, it is sometimes not in our control how much weight we gain or lose. Obesity can be affected by other factors excluding diet, such as, increased leptin resistance in the body, mutated genes in …show more content…
It is usually associated with the part of our brain that sends sensory signals to our body relating to our appetite, called the hypothalamus. Sometimes our fat cells produce excess leptin which causes confusion in the brain regarding the increase in the amount of leptin causing it to ignore the leptin around and making us think that we do not have enough food in our body when we are actually full, as an article on Leptin Resistance stated, “This makes the brain change our physiology and behavior in order to regain the fat that the brain thinks we’re missing”, and as we eat more there is an excess amount of nutrients going into our body causing us to bloat and gain weight. This mechanism called leptin resistance and is classified as a hormonal defect that makes us think that we have less energy so we should eat more and rest because when we lose fat our body thinks that we are starving and we need more fuel to power up the immune system. Leptin resistance can also be caused by an inflammation in the hypothalamus that does not sense the leptin around the brain, as found out this study done on rodents by Stephan Guyenet, “In rodent models, leptin resistance is caused at least in part by inflammatory signaling in the hypothalamus. We can observe this in multiple ways, but one common way is to look at the appearance of specific cells in the brain that change number, size, and shape when inflammation is present”. Showing how when part of the brain forgets to acknowledge the leptin and does not send the right signals to the body a major gain in body weight can be experienced by a person. In all, leptin resistance can cause weight gain and obesity linked with the psychological