Water diuresis in man Essay example

1305 Words Jun 13th, 2014 6 Pages
Water Diuresis in Man Practical Report
INTRODUCTION
The body needs to maintain equilibrium to function properly in everyday life. The most important substance it must regulate is water; water is everywhere in our body and its balance is essential for proper body function.
A very carefully regulated process is solute concentration. If there is a sudden increase in water which enters the extracellular fluid, sodium ions will then contribute less to the extracellular solute concentration as the ratio between water and solute has now changed. Osmolality is the amount of solute in a kilogram, hence the osmolality in the extracellular space has also decreased.
Water diuresis is the increase in urinary water excreted with little or no change
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A single session of vigorous exercise sharply decreases the urine flow and hence, diuresis. During exercise, you lose sodium and water by sweating so the kidney works to reabsorb the water so you are not dehydrated. This results in more concentrated urine.

(b) If a control subject was dehydrated at the beginning of the practical class, how would you expect this to affect their response to the water load?
They would retain some of the water and hence would have decreased urine excretion compared to someone who is well hydrated.

(c) What effect does alcohol have on water diuresis? What is the mechanism of the action of alcohol on a water diuresis?
Alcohol inhibits the pituitary secretion of ADH, which acts on the kidneys to reabsorb water. Because ADH levels drop, the kidneys do not reabsorb as much water and hence produce more urine, causing increased water diuresis.

(d) Use the class graphs and statistical analysis of the urine sodium concentration to determine if this is different for the control and desmopressin subjects. Do you think there a relationship between urine flow and the urine sodium concentration?
According to the statistical analysis, the difference between the control and desmopressin subjects for sodium urine concentration were significantly different. Looking at the class graphs, this is also true; the graph values vary significantly. There seems to be an inverse relationship between urine flow and urine sodium concentration.

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