People in extraordinary situations vulnerable. As participants, they are also threatened by maltreatment or exploitation, and the possibility of damage through research. To protect against these threats, informed consent as an instrument of self-determination set. Self-determination requires autonomous individuals who voluntarily decisions based on doing their morale. But in nursing research, this requirement can not always be met. Advanced age, chronic disease, morbidity and weakness reasons dependencies. This in turn leads to limited abilities or opportunities for decision-making and self-determination. Exclusion of vulnerable people research would hurt them by what their needs, which would violate the ethical principles of justice and mercy.
