Vrsa Research Papers

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VRSA
A Vancomycin Resistance Staphylococcus aureus (VRSA) is a type of antibiotic resistance for staphylococcus bacteria. Staphylococcus aureus is gram-positive cocci in cluster that show catalase and coagulase positive reaction. Staphylococcus bacteria are one of the most common causes of skin infections such as surgical wound infections, septicaemia, pimples and boils. Vancomycin is a glycopeptide antibiotic that inhibits cell wall biosynthesis that remains a drug of choice for treatment of severe MRSA infections. VRSA tends to develop among patients with indwelling catheter and people who have physical contact with infected patient or contaminated stuff such as gauze, plaster and bandage. VRSA also frequently isolated for Methicillin Resistance Staphylococcus aureus (MRSA) infection during vancomycin therapy which fail to treat. …show more content…
The cell has a high osmotic pressure to multiply in an environment with a lower external pressure, they must keep synthesizing a strong extracellular structure called peptidoglycan to prevent the cells from rupturing. To produce peptidoglycan, its monomeric component (murein monomer) must be synthesized inside the cell, and transferred to the outside by lipid carriers present in the cytoplasmic membrane. Accumulation of excess amounts of peptidoglycan will thicken the cell wall resulting in vancomycin resistance. More vancomycin molecules will be trapped in the peptidoglycan layers before reaching the cytoplasmic membrane where peptidoglycan synthesis

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