Virulence Factors Of Diphtheri Corynebacterium Diphtheria

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Corynebacterium diphtheriae
Corynebacterium diphtheria is an organism that frequently causes diphtheria in humans. Diphtheria was once known to be a great cause in the mortality of children, although the disease occurrence has since decreased tremendously due to the creation of the vaccine. There are still instances where the disease can occur. Corynebacterium diphtheriae is characterized by an aerobic, gram-positive bacilli that is non spore forming. It does not possess a capsule/is not encapsulated and is non motile. The optimal temperature of Corynebacterium diphtheriae is 37 degrees.
Corynebacterium diphtheriae is spread through droplet transmission. Although the cutaneous form of Corynebacterium diphtheriae is not as common, contact
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Although there is not much that is known about the other virulence factors, there is agreement that other factors exist and accompany the Diphtheria toxin. One that is suggested is the existence of a colonization factor (1). This allows it to be more successful compared to others in its nasopharyngeal niche, as findings show that lysotypes are existent for a significant course of time before change occurs (1). Recent findings have also shown that the SpaA-type pilus helps with the adhering of the bacteria to the pharyngeal epithelial (2). Corynebacterium diphtheriae as a skin infection is more common in hot places than cold. There are usually no complications that are associated with the diphtheria toxin in skin infections, as compared to the usual mode of infection in humans. Through research, scientists feel that this may be due to low amounts of the secretion of the …show more content…
The exotoxin is able to stop the protein synthesis of cells, which happens after the attachment of the toxin to the receptor on the cell. The A fragment of the toxin is responsible for the inhibition of protein synthesis, and the B subunit is for the cell receptor, which helps with the binding (3). In detail, The A subunit stops the NAD+-dependent ADP-ribosylation of the elongation factor 2 (1). There is no toxin produced unless there is lysogenization by the bacteriophage. There must also be a low level of iron inside the cell There three types of Corynebacterium diphtheriae bacteria. They are known as gravis, intermedius, and mitis. They are categorized by the harmful effect that they cause to the human, as the toxin amount and growth varies in all three types of the bacteria. The gravis strain of bacteria has the shortest replication time, and mitis has the

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