Vincrestine is a plant alkaloid, obtained from the Madagascar periwinkle cathanthus roeus. Before it was used for cancer treatment, the natives of Madagascar used it for the treatment of diabetes and high blood pressure.
Structure of Vincrestine:
Vincristine has two monomer alkaloid parts, catharanthrine and vindoline, with a formyl group on the indole nitrogen of the vindoline skeleton. Formula C46H56N4O10
Disease it Targets:
Vincristine is used to treat various types of cancer. It is a cancer chemotherapy drug that is usually used with other chemotherapy drugs to slow down or stop cancer cell growth. Cancer treatments with vincristine include leukaemia, Hodgkin and non-Hodgkin lymphomas,neuroblastoma, Wilms' tumor, multiple myeloma, rhabdomyosarcoma, ewings sarcoma, chronic leukaemia, thyroid cancer and brain tumours.
Its molecular target:
Highly …show more content…
ADME:
Patients undergoing a positive therapy with vincristine sulphate are reported to suffer from central nervous leukemia. This means that vincristine doesn’t cross the blood brain barrier well.
Pharmacokinetic studies in patients with cancer have exposed that when one is treated with a quick intravenous injection of vincristine a triphasic serum decay sequence is noticed. The range of terminal half–life in humans is from 19 to 155 hours. As the liver is an important organ in the metabolism and excretion of drugs, vincristine metabolism has shown to be mediated by the hepatic cytochrome P450 isoenzymes in the CYP 3A subfamily. However, patients with hepatic dysfunction or those taking a potent inhibitor of the enzyme at the same time as vincristine the metabolic pathway is weakened. Following an injected dose of vincristine sulphate within 15 to 30 minutes, more than 90% of the drug is dispersed into the tissues from the blood where it is strongly bound to tissues but can be reversed. About 80% of it is excreted in the faeces and the rest is found in the