Rhiju Das came to Butler on March 21st to give a lecture on how a videogame has helped code for RNA. Diseases can be traced back to RNA molecule folds. RNA vaccines have a design problem because it is hard to tell what sequence is correct. NUPACK 08 was the most sophisticated computer system and it got the sequence wrong. However, Taipan was designed by a videogamer and it had the correct sequence. Therefore, Das designed a game called Foldit in which players solved puzzles of computers. A new game called EteRNA was developed in which players look at date and design structures. It involved game interface, voting, synthesis, and results, which essentially was the scientific method. Human EteRNA players actually scored higher than computers.
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Because of this, a game within this game was created called Strategy Market. Players explained their rules for sequencing and Das created codes for players to use. The EteRNAbot was created to test these rules. After some tests, the EteRNAbot did about as well as humans and better than computers. Das also mentioned that for every round, there were 1000 designs, but only 32 were synthesized. Players complained that their designs were not being used. DNA chips were created to make a code that way every design gets synthesized.
A new gameplay called Cloud Lab was created. Players come up with totally new projects which leads to massively parallel experiments and tiny papers. The players only had to fill out the conclusion which stated if the hypothesis worked. There were 41,855 sequences and 379 projects that resulted from this. Not many people explore random RNA sequencing, so there is not much scientific literature. Therefore, papers from the players were
Because of this, a game within this game was created called Strategy Market. Players explained their rules for sequencing and Das created codes for players to use. The EteRNAbot was created to test these rules. After some tests, the EteRNAbot did about as well as humans and better than computers. Das also mentioned that for every round, there were 1000 designs, but only 32 were synthesized. Players complained that their designs were not being used. DNA chips were created to make a code that way every design gets synthesized.
A new gameplay called Cloud Lab was created. Players come up with totally new projects which leads to massively parallel experiments and tiny papers. The players only had to fill out the conclusion which stated if the hypothesis worked. There were 41,855 sequences and 379 projects that resulted from this. Not many people explore random RNA sequencing, so there is not much scientific literature. Therefore, papers from the players were