Diabetes mellitus is a condition that affects body’s ability to use the energy found in food. Normally, when body breaks down sugars and carbohydrates, it converts into glucose. With the help of hormone insulin, glucose fuels the cells in human body. In diabetes, many reasons that the cell can’t take glucose. Later, accumulation of glucose in blood can occur. Type 2 diabetes is the most common form in adults. In Type 2 diabetes human body does not use insulin properly. Twenty six million of adults American have been diagnosed with this condition. High level of glucose may damage tiny blood vessels, kidneys, eyes, heart and nervous system. If left untreated, it can invite more serious problem. Thus, researchers have been constantly working to
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Strict glycemic control through diet, exercise and pharmacotherapy intervention is essential. Human kidney has great role in maintaining glucose homeostasis. Gluconeogenesis, glucose utilization and glucose reabsorption are the 3 mechanisms that take place in kidney. Reabsorption has the most important role in supporting glycemic state. SGLT2 is found in the proximal tubules of the kidney and intestine, which contribute to renal glucose reabsorption. “In diabetes 2, filtered glucose in the tubules exceeds the transport maximum and gets excreted via urine even though the transporters continue to function normally” (Dixit. etl, 2015). Empagliflozin is a direct inhibitor of SGLT2, which reduces renal reabsorption of filtered glucose. This medicine helps to drop the renal threshold and increase urinary glucose excretion. Inhibiting SGLT2 results increased glycosuria and drop in plasma glucose concentration. The medicine is useful for diabetic patient since it helps to maintain glycemic homeostasis. It does not depend on insulin. Blood sugar can be controlled without having any risk of low blood sugar. Empagliflozin may use in different stage of diabetes with nonfunctional or impaired pancreatic b cells. The medicine can be used with other diabetic medicine as well. Consuming food does not affect concentration of this drug. Four weeks trail of medicine once daily with type 2 diabetes …show more content…
Assess patient for any sign and symptom of ketoacidosis including nausea, vomiting, difficulty breathing, confusion sleepiness, fatigue, abdominal pain etc. Monitor patient’s blood sugar. Notify to health care provider if any symptom persist or go the emergency department. Medical treatment, nursing care, awareness and patient education are necessary factors to prevent from getting worsening condition. Increase glucose in the urine may cause genital infection. Peri care and maintaining hygiene can prevent genital tract infection. Apply medicine as necessary for fungal infection such as antifungal cream or powder. Maintain fluid and electrolyte balance is important to prevent volume
Strict glycemic control through diet, exercise and pharmacotherapy intervention is essential. Human kidney has great role in maintaining glucose homeostasis. Gluconeogenesis, glucose utilization and glucose reabsorption are the 3 mechanisms that take place in kidney. Reabsorption has the most important role in supporting glycemic state. SGLT2 is found in the proximal tubules of the kidney and intestine, which contribute to renal glucose reabsorption. “In diabetes 2, filtered glucose in the tubules exceeds the transport maximum and gets excreted via urine even though the transporters continue to function normally” (Dixit. etl, 2015). Empagliflozin is a direct inhibitor of SGLT2, which reduces renal reabsorption of filtered glucose. This medicine helps to drop the renal threshold and increase urinary glucose excretion. Inhibiting SGLT2 results increased glycosuria and drop in plasma glucose concentration. The medicine is useful for diabetic patient since it helps to maintain glycemic homeostasis. It does not depend on insulin. Blood sugar can be controlled without having any risk of low blood sugar. Empagliflozin may use in different stage of diabetes with nonfunctional or impaired pancreatic b cells. The medicine can be used with other diabetic medicine as well. Consuming food does not affect concentration of this drug. Four weeks trail of medicine once daily with type 2 diabetes …show more content…
Assess patient for any sign and symptom of ketoacidosis including nausea, vomiting, difficulty breathing, confusion sleepiness, fatigue, abdominal pain etc. Monitor patient’s blood sugar. Notify to health care provider if any symptom persist or go the emergency department. Medical treatment, nursing care, awareness and patient education are necessary factors to prevent from getting worsening condition. Increase glucose in the urine may cause genital infection. Peri care and maintaining hygiene can prevent genital tract infection. Apply medicine as necessary for fungal infection such as antifungal cream or powder. Maintain fluid and electrolyte balance is important to prevent volume