Choice “E” is the best answer. This patient has nocardiosis. Trimethoprim-sulfamethoxazole antibiotic therapy inhibits bacterial growth by inhibiting successive steps in the synthesis of dihydrofolic acid. Sulfonamides have long been the first-line antimicrobial therapy for nocardiosis. Among the sulfonamides, sulfadiazine is generally preferred because of its CNS and CSF penetration. Trimethoprim-sulfamethoxazole (TMP-SMZ) is considered the therapy of choice by most authorities.
Choice “A” is not the best answer. Amoxicillin alone is not effective in the treatment of nocardiosis. Amoxicillin/clavulanate in addition to linezolid may be used initially only in the treatment of mild-to-moderately severe disease or as sequential therapy after
Choice “A” is not the best answer. Amoxicillin alone is not effective in the treatment of nocardiosis. Amoxicillin/clavulanate in addition to linezolid may be used initially only in the treatment of mild-to-moderately severe disease or as sequential therapy after