Topical Nerve Growth Factor (NGF) Application
In an animal model the topical application of NGF to wounds and ulcers leads to a statistically significant decrease in the wound perimeter (66%) vs. controls.[8, 23, 77, 120] Clinically, topical application of NGF leads to the repair of neurotrophic corneal ulcers, recovery of corneal surface sensitivity [36, 119] and diabetic foot ulcers.[73]
Basic Fibroblast Growth Factor (bFGF)
Topical application of bFGF enhances the healing for operative wounds, burns, chronic dermal ulcers and diabetic ulcers about 2-fold faster than untreated wounds.[10, 72, 153, 157, 227] The influence is proposed to result from inducing the proliferation of otherwise non-proliferating cells
Recombinant Human Erythropoietin …show more content…
A patient’s good nutritional status is essential for wound healing with protein deficiency contributing to poor healing rates.[90, 134, 169, 185] Skin break-down can result in a deficit of as much as 100 gm of protein in one day.[185] There is a correlation between low serum albumin and body mass index (BMI) and the development of pressure ulcers.[122] The topical application of essential fatty acids to the entire body, including potential wound sites, improves tissue hydration and elasticity and helps prevent skin breakdown in individuals with a poor nutritional status.[48, 169] This application results in a 36% reduction in the development of pressure …show more content…
VAC therapy increases wound blood flow, promotes angiogenesis and subsequent formation of healthy tissue, speeds the formation of granulation tissue, and decreases accumulation of fluid and bacteria to accelerate healing[130], and is effective on all categories of pressure ulcers tested [130, 200] with an average size reduction of 55%.[89] VAC therapy enhances more extensive healing than both alginate and hydrocolloid dressings[200], with patients receiving negative pressure wound therapy experiencing lower rates of hospitalization (35% vs. 48%) due to wound problems (5% vs. 14%,), and emergent care for wound problems (0% vs.
In an animal model the topical application of NGF to wounds and ulcers leads to a statistically significant decrease in the wound perimeter (66%) vs. controls.[8, 23, 77, 120] Clinically, topical application of NGF leads to the repair of neurotrophic corneal ulcers, recovery of corneal surface sensitivity [36, 119] and diabetic foot ulcers.[73]
Basic Fibroblast Growth Factor (bFGF)
Topical application of bFGF enhances the healing for operative wounds, burns, chronic dermal ulcers and diabetic ulcers about 2-fold faster than untreated wounds.[10, 72, 153, 157, 227] The influence is proposed to result from inducing the proliferation of otherwise non-proliferating cells
Recombinant Human Erythropoietin …show more content…
A patient’s good nutritional status is essential for wound healing with protein deficiency contributing to poor healing rates.[90, 134, 169, 185] Skin break-down can result in a deficit of as much as 100 gm of protein in one day.[185] There is a correlation between low serum albumin and body mass index (BMI) and the development of pressure ulcers.[122] The topical application of essential fatty acids to the entire body, including potential wound sites, improves tissue hydration and elasticity and helps prevent skin breakdown in individuals with a poor nutritional status.[48, 169] This application results in a 36% reduction in the development of pressure …show more content…
VAC therapy increases wound blood flow, promotes angiogenesis and subsequent formation of healthy tissue, speeds the formation of granulation tissue, and decreases accumulation of fluid and bacteria to accelerate healing[130], and is effective on all categories of pressure ulcers tested [130, 200] with an average size reduction of 55%.[89] VAC therapy enhances more extensive healing than both alginate and hydrocolloid dressings[200], with patients receiving negative pressure wound therapy experiencing lower rates of hospitalization (35% vs. 48%) due to wound problems (5% vs. 14%,), and emergent care for wound problems (0% vs.